Impact of human T-cell leukemia virus type 1 on living donor liver transplantation : a multi-center study in Japan
© 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery..
BACKGROUND: The natural history of human T-cell leukemia virus type 1 (HTLV-1), which causes adult T-cell leukemia (ATL) or HTLV-1 associated myelopathy, after liver transplantation is unclear.
METHODS: We conducted a nationwide survey to investigate the impact of HTLV-1 status on living donor liver transplantation (LDLT) in Japan. We analyzed the cases of 82 HTLV-1-positive recipients and six HTLV-1-negative-before-LDLT recipients who received a hepatic graft from HTLV-1-positive donors.
RESULTS: Adult T-cell leukemia developed in five recipients who ultimately died. Of these five, two received grafts from HTLV-1-positive donors and three from HTLV-1-negative donors. The 1-, 3-, and 5-year ATL development rates were 4.5%, 6.5%, and 9.2%, respectively. Fulminant hepatic failure as a pre-transplant diagnosis was identified as an independent risk factor for ATL development (P = 0.001). The 1-, 3-, and 5-year survival rates for HTLV-1-positive recipients who received grafts from HTLV-1-negative donors were 79.9%, 66.1%, and 66.1%, and from HTLV-1-positive donors were 83.3%, 83.3%, and 60.8%, respectively. The 1-year survival rate for HTLV-1-negative recipients who received grafts from HTLV-1-positive donors was 33.3%.
CONCLUSIONS: Fulminant hepatic failure is an independent risk factor for ATL development in HTLV-1-positive recipients. Grafts from HTLV-1-positive living donors can be transplanted into selected patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Journal of hepato-biliary-pancreatic sciences - 23(2016), 6 vom: 21. Juni, Seite 333-41 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yoshizumi, Tomoharu [VerfasserIn] |
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| Links: |
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| Themen: |
Adult T-cell leukemia |
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| Anmerkungen: |
Date Completed 07.08.2017 Date Revised 07.08.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jhbp.345 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM258612916 |
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| 100 | 1 | |a Yoshizumi, Tomoharu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of human T-cell leukemia virus type 1 on living donor liver transplantation |b a multi-center study in Japan |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery. | ||
| 520 | |a BACKGROUND: The natural history of human T-cell leukemia virus type 1 (HTLV-1), which causes adult T-cell leukemia (ATL) or HTLV-1 associated myelopathy, after liver transplantation is unclear | ||
| 520 | |a METHODS: We conducted a nationwide survey to investigate the impact of HTLV-1 status on living donor liver transplantation (LDLT) in Japan. We analyzed the cases of 82 HTLV-1-positive recipients and six HTLV-1-negative-before-LDLT recipients who received a hepatic graft from HTLV-1-positive donors | ||
| 520 | |a RESULTS: Adult T-cell leukemia developed in five recipients who ultimately died. Of these five, two received grafts from HTLV-1-positive donors and three from HTLV-1-negative donors. The 1-, 3-, and 5-year ATL development rates were 4.5%, 6.5%, and 9.2%, respectively. Fulminant hepatic failure as a pre-transplant diagnosis was identified as an independent risk factor for ATL development (P = 0.001). The 1-, 3-, and 5-year survival rates for HTLV-1-positive recipients who received grafts from HTLV-1-negative donors were 79.9%, 66.1%, and 66.1%, and from HTLV-1-positive donors were 83.3%, 83.3%, and 60.8%, respectively. The 1-year survival rate for HTLV-1-negative recipients who received grafts from HTLV-1-positive donors was 33.3% | ||
| 520 | |a CONCLUSIONS: Fulminant hepatic failure is an independent risk factor for ATL development in HTLV-1-positive recipients. Grafts from HTLV-1-positive living donors can be transplanted into selected patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Adult T-cell leukemia | |
| 650 | 4 | |a Human T-cell leukemia virus type 1 | |
| 650 | 4 | |a Living donor liver transplantation | |
| 700 | 1 | |a Takada, Yasutsugu |e verfasserin |4 aut | |
| 700 | 1 | |a Shirabe, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Kaido, Toshimi |e verfasserin |4 aut | |
| 700 | 1 | |a Hidaka, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Honda, Masaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Shinoda, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ohdan, Hideki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawagishi, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sugawara, Yasuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Ogura, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kasahara, Mureo |e verfasserin |4 aut | |
| 700 | 1 | |a Kubo, Shoji |e verfasserin |4 aut | |
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| 700 | 1 | |a Yamashita, Natsumi |e verfasserin |4 aut | |
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| 700 | 1 | |a Takada, Tadahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Maehara, Yoshihiko |e verfasserin |4 aut | |
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