Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa : Possible role in recurrent pregnancy loss
Contribution from a defective paternal genome has been attributed to be an important cause for spontaneous recurrent pregnancy loss (RPL). Increased oxidative stress results in decreased detoxification and is a cause for damage to chromatin, proteins, and membrane lipids. The present study aimed to explore if there is a significant relationship between retained histones due to defective packaging of DNA in spermatozoa and oxidative stress. RPL patients (n=16) with a history of ≥2 embryo losses before the 20th week of gestation and no female factor abnormality, and fertile healthy volunteers (n=20) as controls were included in the study. A significant difference in the levels of protein carbonylation and lipid peroxidation together with an increased retention of histones in the experimental groups was noticed. Histone carrying sites for oxidative modification such as arginine and lysine might be responsible for disturbing the paternal epigenomic control during early stages of embryonic differentiation leading to abortion.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
|---|---|
| Enthalten in: |
Systems biology in reproductive medicine - 62(2016), 3 vom: 07. Juni, Seite 201-12 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mohanty, Gayatri [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Histone retention |
|---|
| Anmerkungen: |
Date Completed 04.04.2017 Date Revised 04.04.2017 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.3109/19396368.2016.1148798 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM25845296X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM25845296X | ||
| 003 | DE-627 | ||
| 005 | 20231224185038.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3109/19396368.2016.1148798 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0861.xml |
| 035 | |a (DE-627)NLM25845296X | ||
| 035 | |a (NLM)26980262 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mohanty, Gayatri |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Histone retention, protein carbonylation, and lipid peroxidation in spermatozoa |b Possible role in recurrent pregnancy loss |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.04.2017 | ||
| 500 | |a Date Revised 04.04.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Contribution from a defective paternal genome has been attributed to be an important cause for spontaneous recurrent pregnancy loss (RPL). Increased oxidative stress results in decreased detoxification and is a cause for damage to chromatin, proteins, and membrane lipids. The present study aimed to explore if there is a significant relationship between retained histones due to defective packaging of DNA in spermatozoa and oxidative stress. RPL patients (n=16) with a history of ≥2 embryo losses before the 20th week of gestation and no female factor abnormality, and fertile healthy volunteers (n=20) as controls were included in the study. A significant difference in the levels of protein carbonylation and lipid peroxidation together with an increased retention of histones in the experimental groups was noticed. Histone carrying sites for oxidative modification such as arginine and lysine might be responsible for disturbing the paternal epigenomic control during early stages of embryonic differentiation leading to abortion | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Histone retention | |
| 650 | 4 | |a lipid peroxidation | |
| 650 | 4 | |a protein carbonyl | |
| 650 | 4 | |a recurrent pregnancy loss | |
| 650 | 7 | |a Histones |2 NLM | |
| 700 | 1 | |a Swain, Nirlipta |e verfasserin |4 aut | |
| 700 | 1 | |a Goswami, Chandan |e verfasserin |4 aut | |
| 700 | 1 | |a Kar, Sujata |e verfasserin |4 aut | |
| 700 | 1 | |a Samanta, Luna |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Systems biology in reproductive medicine |d 2008 |g 62(2016), 3 vom: 07. Juni, Seite 201-12 |w (DE-627)NLM179253867 |x 1939-6376 |7 nnns |
| 773 | 1 | 8 | |g volume:62 |g year:2016 |g number:3 |g day:07 |g month:06 |g pages:201-12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3109/19396368.2016.1148798 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 62 |j 2016 |e 3 |b 07 |c 06 |h 201-12 | ||