Anti-tubercular therapy for intraocular tuberculosis : A systematic review and meta-analysis
Copyright © 2016 Elsevier Inc. All rights reserved..
Intraocular tuberculosis remains a diagnostic and management conundrum for both ophthalmologists and pulmonologists. We analyze the efficacy and safety of anti-tubercular therapy (ATT) in patients with intraocular tuberculosis and factors associated with favorable outcome. Twenty-eight studies are included in this review, with a total of 1,917 patients. Nonrecurrence of inflammation was observed in pooled estimate of 84% of ATT-treated patients (95% CI 79-89). There was minimal difference in the outcome between patients treated with ATT alone (85% successful outcome; 95% CI 25-100) and those with concomitant systemic corticosteroid (82%; 95% CI 73-90). The use of ATT may be of benefit to patients with suspected intraocular tuberculosis; however, this conclusion is limited by the lack of control group analysis and standardized recruitment and treatment protocols. We propose further prospective studies to better establish the efficacy of ATT and ascertain the factors associated with favorable treatment outcomes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
|---|---|
| Enthalten in: |
Survey of ophthalmology - 61(2016), 5 vom: 01. Sept., Seite 628-53 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kee, Ae Ra [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Anti-Inflammatory Agents |
|---|
| Anmerkungen: |
Date Completed 02.05.2017 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.survophthal.2016.03.001 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM258358424 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM258358424 | ||
| 003 | DE-627 | ||
| 005 | 20231224184835.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.survophthal.2016.03.001 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0861.xml |
| 035 | |a (DE-627)NLM258358424 | ||
| 035 | |a (NLM)26970263 | ||
| 035 | |a (PII)S0039-6257(15)30050-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kee, Ae Ra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-tubercular therapy for intraocular tuberculosis |b A systematic review and meta-analysis |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.05.2017 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Inc. All rights reserved. | ||
| 520 | |a Intraocular tuberculosis remains a diagnostic and management conundrum for both ophthalmologists and pulmonologists. We analyze the efficacy and safety of anti-tubercular therapy (ATT) in patients with intraocular tuberculosis and factors associated with favorable outcome. Twenty-eight studies are included in this review, with a total of 1,917 patients. Nonrecurrence of inflammation was observed in pooled estimate of 84% of ATT-treated patients (95% CI 79-89). There was minimal difference in the outcome between patients treated with ATT alone (85% successful outcome; 95% CI 25-100) and those with concomitant systemic corticosteroid (82%; 95% CI 73-90). The use of ATT may be of benefit to patients with suspected intraocular tuberculosis; however, this conclusion is limited by the lack of control group analysis and standardized recruitment and treatment protocols. We propose further prospective studies to better establish the efficacy of ATT and ascertain the factors associated with favorable treatment outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a anti-tubercular therapy | |
| 650 | 4 | |a intraocular | |
| 650 | 4 | |a tuberculosis | |
| 650 | 4 | |a uveitis | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Antitubercular Agents |2 NLM | |
| 700 | 1 | |a Gonzalez-Lopez, Julio J |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hity, Aws |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Bhaskar |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Cecilia S |e verfasserin |4 aut | |
| 700 | 1 | |a Gunasekeran, Dinesh Visva |e verfasserin |4 aut | |
| 700 | 1 | |a Jayabalan, Nirmal |e verfasserin |4 aut | |
| 700 | 1 | |a Grant, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Kon, Onn Min |e verfasserin |4 aut | |
| 700 | 1 | |a Gupta, Vishali |e verfasserin |4 aut | |
| 700 | 1 | |a Westcott, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Pavesio, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Agrawal, Rupesh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Survey of ophthalmology |d 1956 |g 61(2016), 5 vom: 01. Sept., Seite 628-53 |w (DE-627)NLM000142956 |x 1879-3304 |7 nnns |
| 773 | 1 | 8 | |g volume:61 |g year:2016 |g number:5 |g day:01 |g month:09 |g pages:628-53 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.survophthal.2016.03.001 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 61 |j 2016 |e 5 |b 01 |c 09 |h 628-53 | ||