Increased coagulation and fibrinolytic potential of solvent-detergent plasma : a comparative study between Omniplasma and fresh frozen plasma
© 2016 International Society of Blood Transfusion..
BACKGROUND AND OBJECTIVES: In this study, differences in levels of proteins involved in coagulation and fibrinolysis were compared between fresh frozen (quarantine plasma) and Omniplasma. Furthermore, thawing conditions and plasma stability after thawing were studied.
MATERIALS AND METHODS: 10 Omniplasma and 10 quarantine plasma units were used to study different procoagulation, anticoagulation and fibrinolytic parameters. Analysis took place at different time-points during plasma storage at 2-6°C.
RESULTS: At baseline, significant reduced levels of factor V, free protein S, α2-antiplasmin and tPA-induced ROTEM lysis time were observed in Omniplasma as compared to quarantine plasma. Moreover, thrombin generation, IXa-AT complex levels and factor XIa were significantly increased in Omniplasma. The majority of the parameters studied remained stable in Omniplasma 48 h after thawing, with the exception of factor VIII (decrease) and IXa-AT (increase).
CONCLUSION: Our results suggest an increased coagulation potential, presumingly as a result of contact activation during the production process and also, an increased fibrinolytic potential in Omniplasma. The stability of Omniplasma, based upon the different parameters studied, is comparable to Q-plasma. A maximum post-thawing time of 48 hfor Omniplasma can be suggested.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
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| Enthalten in: |
Vox sanguinis - 111(2016), 1 vom: 01. Juli, Seite 33-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Beers, J J B C [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 14.12.2016 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/vox.12395 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257958061 |
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| 100 | 1 | |a van Beers, J J B C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased coagulation and fibrinolytic potential of solvent-detergent plasma |b a comparative study between Omniplasma and fresh frozen plasma |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 14.12.2016 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 International Society of Blood Transfusion. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: In this study, differences in levels of proteins involved in coagulation and fibrinolysis were compared between fresh frozen (quarantine plasma) and Omniplasma. Furthermore, thawing conditions and plasma stability after thawing were studied | ||
| 520 | |a MATERIALS AND METHODS: 10 Omniplasma and 10 quarantine plasma units were used to study different procoagulation, anticoagulation and fibrinolytic parameters. Analysis took place at different time-points during plasma storage at 2-6°C | ||
| 520 | |a RESULTS: At baseline, significant reduced levels of factor V, free protein S, α2-antiplasmin and tPA-induced ROTEM lysis time were observed in Omniplasma as compared to quarantine plasma. Moreover, thrombin generation, IXa-AT complex levels and factor XIa were significantly increased in Omniplasma. The majority of the parameters studied remained stable in Omniplasma 48 h after thawing, with the exception of factor VIII (decrease) and IXa-AT (increase) | ||
| 520 | |a CONCLUSION: Our results suggest an increased coagulation potential, presumingly as a result of contact activation during the production process and also, an increased fibrinolytic potential in Omniplasma. The stability of Omniplasma, based upon the different parameters studied, is comparable to Q-plasma. A maximum post-thawing time of 48 hfor Omniplasma can be suggested | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Omniplasma | |
| 650 | 4 | |a quarantine plasma | |
| 650 | 4 | |a solvent-detergent plasma | |
| 650 | 7 | |a Detergents |2 NLM | |
| 650 | 7 | |a Solvents |2 NLM | |
| 650 | 7 | |a alpha-2-Antiplasmin |2 NLM | |
| 650 | 7 | |a Factor IXa |2 NLM | |
| 650 | 7 | |a EC 3.4.21.22 |2 NLM | |
| 650 | 7 | |a Factor XIa |2 NLM | |
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| 650 | 7 | |a Tissue Plasminogen Activator |2 NLM | |
| 650 | 7 | |a EC 3.4.21.68 |2 NLM | |
| 700 | 1 | |a van Egmond, L T |e verfasserin |4 aut | |
| 700 | 1 | |a Wetzels, R J H |e verfasserin |4 aut | |
| 700 | 1 | |a Verhezen, P W M |e verfasserin |4 aut | |
| 700 | 1 | |a Beckers, E A M |e verfasserin |4 aut | |
| 700 | 1 | |a van Oerle, R |e verfasserin |4 aut | |
| 700 | 1 | |a Spronk, H M H |e verfasserin |4 aut | |
| 700 | 1 | |a Straat, R J M H E |e verfasserin |4 aut | |
| 700 | 1 | |a Henskens, Y M C |e verfasserin |4 aut | |
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