Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients
Copyright © 2016 Elsevier B.V. All rights reserved..
OBJECTIVES: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis.
METHODS: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >2mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared.
RESULTS: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p=0.003) and comprised more past/current smokers (43 vs 15%, p=0.0007). Aortic aneurisms were more frequent (38% vs 20%, p=0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median=34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p=0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p=0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis.
CONCLUSIONS: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients <60 years. Most patients with IA ≥ 60 years share many features with GCA-related aortitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Autoimmunity reviews - 15(2016), 6 vom: 18. Juni, Seite 571-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Espitia, Olivier [VerfasserIn] |
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| Links: |
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| Themen: |
Aortic aneurysm |
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| Anmerkungen: |
Date Completed 15.12.2016 Date Revised 09.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.autrev.2016.02.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257731725 |
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| 041 | |a eng | ||
| 100 | 1 | |a Espitia, Olivier |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Comparison of idiopathic (isolated) aortitis and giant cell arteritis-related aortitis. A French retrospective multicenter study of 117 patients |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 15.12.2016 | ||
| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVES: The aim of the study was to compare clinical/imaging findings and outcome in patients with idiopathic (isolated aortitis, IA) and with giant cell arteritis (GCA)-related aortitis | ||
| 520 | |a METHODS: Patients from 11 French internal medicine departments were retrospectively included. Aortitis was defined by aortic wall thickening >2mm and/or an aortic aneurysm on CT-scan, associated to inflammatory syndrome. Patients with GCA had at least 3 ACR criteria. Aortic events (aneurysm, dissection, aortic surgeries) were reported, and free of aortic events-survival were compared | ||
| 520 | |a RESULTS: Among 191 patients with non-infectious aortitis, 73 with GCA and 44 with IA were included. Patients with IA were younger (65 vs 70 years, p=0.003) and comprised more past/current smokers (43 vs 15%, p=0.0007). Aortic aneurisms were more frequent (38% vs 20%, p=0.03), and aortic wall thickening was more pronounced in IA. During follow-up (median=34 months), subsequent development of aortic aneurysm was significantly lower in GCA when compared to IA (p=0.009). GCA patients required significantly less aortic surgery during follow-up than IA patients (p=0.02). Mean age, sex ratio, inflammatory parameters, and free of aortic aneurism survival were equivalent in patients with IA ≥ 60 years when compared to patients with GCA-related aortitis | ||
| 520 | |a CONCLUSIONS: IA is more severe than aortitis related to GCA, with higher proportions of aortic aneurism at diagnosis and during follow-up. IA is a heterogeneous disease and its prognosis is worse in younger patients <60 years. Most patients with IA ≥ 60 years share many features with GCA-related aortitis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Aortic aneurysm | |
| 650 | 4 | |a Aortitis | |
| 650 | 4 | |a Giant cell arteritis | |
| 650 | 4 | |a Idiopathic aortitis | |
| 650 | 4 | |a Isolated aortitis | |
| 700 | 1 | |a Samson, Maxime |e verfasserin |4 aut | |
| 700 | 1 | |a Le Gallou, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Connault, Jérôme |e verfasserin |4 aut | |
| 700 | 1 | |a Landron, Cedric |e verfasserin |4 aut | |
| 700 | 1 | |a Lavigne, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Belizna, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Magnant, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a de Moreuil, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Roblot, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Maillot, François |e verfasserin |4 aut | |
| 700 | 1 | |a Diot, Elisabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Jégo, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Durant, Cécile |e verfasserin |4 aut | |
| 700 | 1 | |a Masseau, A |e verfasserin |4 aut | |
| 700 | 1 | |a Brisseau, Jean-Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Pottier, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Espitia-Thibault, Alexandra |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Anabele Dos |e verfasserin |4 aut | |
| 700 | 1 | |a Perrin, François |e verfasserin |4 aut | |
| 700 | 1 | |a Artifoni, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Néel, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Graveleau, Julie |e verfasserin |4 aut | |
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| 700 | 1 | |a Maisonneuve, Hervé |e verfasserin |4 aut | |
| 700 | 1 | |a Fau, Georges |e verfasserin |4 aut | |
| 700 | 1 | |a Serfaty, Jean-Michel |e verfasserin |4 aut | |
| 700 | 1 | |a Hamidou, Mohamed |e verfasserin |4 aut | |
| 700 | 1 | |a Agard, Christian |e verfasserin |4 aut | |
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