Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
Copyright © 2016 Elsevier Ltd. All rights reserved..
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 26(2016), 6 vom: 15. März, Seite 1525-1528 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tarver, James E [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.11.2016 Date Revised 28.07.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2016.02.021 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257675221 |
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| 520 | |a Copyright © 2016 Elsevier Ltd. All rights reserved. | ||
| 520 | |a A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Femur cortical bone thickness | |
| 650 | 4 | |a Notum Pectinacetylesterase | |
| 650 | 4 | |a Osteoporosis | |
| 650 | 4 | |a SAR | |
| 650 | 4 | |a Thienopyrimidine | |
| 650 | 7 | |a Enzyme Inhibitors |2 NLM | |
| 650 | 7 | |a Pyrimidines |2 NLM | |
| 650 | 7 | |a thienopyrimidine |2 NLM | |
| 650 | 7 | |a Esterases |2 NLM | |
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| 700 | 1 | |a Pabba, Praveen K |e verfasserin |4 aut | |
| 700 | 1 | |a Barbosa, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Qiang |e verfasserin |4 aut | |
| 700 | 1 | |a Gardyan, Michael W |e verfasserin |4 aut | |
| 700 | 1 | |a Brommage, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Thompson, Andrea Y |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, James M |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Alan G E |e verfasserin |4 aut | |
| 700 | 1 | |a He, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lombardo, Victoria K |e verfasserin |4 aut | |
| 700 | 1 | |a Carson, Kenneth G |e verfasserin |4 aut | |
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