Vascular Risk Factors and Cognition in Parkinson's Disease
Vascular risk factors have been associated with cognitive deficits and incident dementia in the general population, but their role on cognitive dysfunction in Parkinson's disease (PD) is still unclear. The present study addresses the single and cumulative effect of vascular risk factors on cognition in PD patients, taking clinical confounders into account. Standardized neuropsychological assessment was performed in 238 consecutive PD patients. We evaluated the association of single and cumulative vascular risk factors (smoking, diabetes, hypercholesterolemia, hypertension, and heart disease), with the diagnosis of PD normal cognition (PDNC, n = 94), mild cognitive impairment (PD-MCI, n = 111), and dementia (PDD, n = 33). The association between single neuropsychological tests and vascular risk factors was evaluated with covariance analyses adjusted for age at onset, educational levels, gender, disease duration, and motor performance. Age, educational levels, disease duration, and motor function were significantly different between PDNC, PD-MCI, and PDD. Heart disease was the only vascular factor significantly more prevalent in PDD compared with PDNC in adjusted analyses. Performance of tests assessing executive and attention functions were significantly worse in patients with hypertension, heart disease, and/or diabetes (p < 0.05). Heart disease is associated with dementia in PD, suggesting a potential window of intervention. Vascular risk factors act especially on attention and executive functions in PD. Vascular risk stratification may be useful in order to identify PD patients with a greater risk of developing dementia. These findings need to be verified in longitudinal studies.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Journal of Alzheimer's disease : JAD - 51(2016), 2 vom: 29., Seite 563-70 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pilotto, Andrea [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Dementia |
|---|
| Anmerkungen: |
Date Completed 20.12.2016 Date Revised 08.04.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.3233/JAD-150610 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM257607781 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM257607781 | ||
| 003 | DE-627 | ||
| 005 | 20231224183209.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3233/JAD-150610 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0858.xml |
| 035 | |a (DE-627)NLM257607781 | ||
| 035 | |a (NLM)26890741 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Pilotto, Andrea |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vascular Risk Factors and Cognition in Parkinson's Disease |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.12.2016 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Vascular risk factors have been associated with cognitive deficits and incident dementia in the general population, but their role on cognitive dysfunction in Parkinson's disease (PD) is still unclear. The present study addresses the single and cumulative effect of vascular risk factors on cognition in PD patients, taking clinical confounders into account. Standardized neuropsychological assessment was performed in 238 consecutive PD patients. We evaluated the association of single and cumulative vascular risk factors (smoking, diabetes, hypercholesterolemia, hypertension, and heart disease), with the diagnosis of PD normal cognition (PDNC, n = 94), mild cognitive impairment (PD-MCI, n = 111), and dementia (PDD, n = 33). The association between single neuropsychological tests and vascular risk factors was evaluated with covariance analyses adjusted for age at onset, educational levels, gender, disease duration, and motor performance. Age, educational levels, disease duration, and motor function were significantly different between PDNC, PD-MCI, and PDD. Heart disease was the only vascular factor significantly more prevalent in PDD compared with PDNC in adjusted analyses. Performance of tests assessing executive and attention functions were significantly worse in patients with hypertension, heart disease, and/or diabetes (p < 0.05). Heart disease is associated with dementia in PD, suggesting a potential window of intervention. Vascular risk factors act especially on attention and executive functions in PD. Vascular risk stratification may be useful in order to identify PD patients with a greater risk of developing dementia. These findings need to be verified in longitudinal studies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dementia | |
| 650 | 4 | |a Parkinson disease | |
| 650 | 4 | |a heart disease | |
| 650 | 4 | |a hypertension | |
| 650 | 4 | |a risk factors | |
| 700 | 1 | |a Turrone, Rosanna |e verfasserin |4 aut | |
| 700 | 1 | |a Liepelt-Scarfone, Inga |e verfasserin |4 aut | |
| 700 | 1 | |a Bianchi, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Poli, Loris |e verfasserin |4 aut | |
| 700 | 1 | |a Borroni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Alberici, Antonella |e verfasserin |4 aut | |
| 700 | 1 | |a Premi, Enrico |e verfasserin |4 aut | |
| 700 | 1 | |a Formenti, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Bigni, Barbara |e verfasserin |4 aut | |
| 700 | 1 | |a Cosseddu, Maura |e verfasserin |4 aut | |
| 700 | 1 | |a Cottini, Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Berg, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Padovani, Alessandro |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of Alzheimer's disease : JAD |d 1998 |g 51(2016), 2 vom: 29., Seite 563-70 |w (DE-627)NLM097527327 |x 1875-8908 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2016 |g number:2 |g day:29 |g pages:563-70 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.3233/JAD-150610 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 51 |j 2016 |e 2 |b 29 |h 563-70 | ||