Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease
Copyright © 2016 Elsevier Ltd. All rights reserved..
Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8(+) T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
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| Enthalten in: |
Cytokine - 82(2016) vom: 12. Juni, Seite 102-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cepero-Donates, Yuneivy [VerfasserIn] |
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| Links: |
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| Themen: |
Chemokines |
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| Anmerkungen: |
Date Completed 14.12.2017 Date Revised 10.02.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cyto.2016.01.020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257390286 |
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| 245 | 1 | 0 | |a Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8(+) T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Interleukin-15 | |
| 650 | 4 | |a Liver | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a NAFLD | |
| 650 | 7 | |a Chemokines |2 NLM | |
| 650 | 7 | |a Dietary Fats |2 NLM | |
| 650 | 7 | |a Il15ra protein, mouse |2 NLM | |
| 650 | 7 | |a Interleukin-15 |2 NLM | |
| 650 | 7 | |a Receptors, Interleukin-15 |2 NLM | |
| 700 | 1 | |a Lacraz, Grégory |e verfasserin |4 aut | |
| 700 | 1 | |a Ghobadi, Farnaz |e verfasserin |4 aut | |
| 700 | 1 | |a Rakotoarivelo, Volatiana |e verfasserin |4 aut | |
| 700 | 1 | |a Orkhis, Sakina |e verfasserin |4 aut | |
| 700 | 1 | |a Mayhue, Marian |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yi-Guang |e verfasserin |4 aut | |
| 700 | 1 | |a Rola-Pleszczynski, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Menendez, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Ilangumaran, Subburaj |e verfasserin |4 aut | |
| 700 | 1 | |a Ramanathan, Sheela |e verfasserin |4 aut | |
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