Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment : A pilot study
INTRODUCTION: Acute intermittent hypoxia (AIH) enhances lower extremity motor function in humans with chronic incomplete spinal cord injury (SCI). AIH-induced spinal plasticity is inhibited by systemic inflammation in animal models. Since SCI is frequently associated with systemic inflammation in humans, we tested the hypothesis that pretreatment with the anti-inflammatory agent ibuprofen enhances the effects of AIH.
METHODS: A randomized, double-blinded, placebo-controlled crossover design was used. Nine adults (mean age 51.1 ± 13.1 years) with chronic motor-incomplete SCI (7.7 ± 6.3 years post-injury) received a single dose of ibuprofen (800 mg) or placebo, 90 minutes prior to AIH. For AIH, 9% O2 for 90 seconds was interspersed with 21% O2 for 60 seconds. Maximal voluntary ankle plantar flexion isometric torque was assessed prior to, and at 0, 30, and 60 minutes post-AIH. Surface electromyography (EMG) of plantar flexor muscles was also recorded.
RESULTS: Torque increased significantly after AIH at 30 (P = 0.007; by ∼20%) and 60 (P < 0.001; by ∼30%) minutes post-AIH versus baseline. Ibuprofen did not augment the effects of AIH. EMG activity did not increase significantly after AIH; however, there was a significant association between increases in torque and EMG in both gastrocnemius (R2 = 0.17, P < 0.005) and soleus (R2 = 0.17, P < 0.005) muscles.
CONCLUSIONS: AIH systematically increased lower extremity torque in individuals with chronic incomplete SCI, but there was no significant effect of ibuprofen pretreatment. Our study re-confirms the ability of AIH to enhance leg strength in persons with chronic incomplete SCI.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
The journal of spinal cord medicine - 40(2017), 3 vom: 18. Mai, Seite 295-303 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lynch, Meaghan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 05.03.2018 Date Revised 26.11.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10790268.2016.1142137 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257279016 |
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| 100 | 1 | |a Lynch, Meaghan |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of acute intermittent hypoxia on motor function in individuals with chronic spinal cord injury following ibuprofen pretreatment |b A pilot study |
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| 500 | |a Date Revised 26.11.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Acute intermittent hypoxia (AIH) enhances lower extremity motor function in humans with chronic incomplete spinal cord injury (SCI). AIH-induced spinal plasticity is inhibited by systemic inflammation in animal models. Since SCI is frequently associated with systemic inflammation in humans, we tested the hypothesis that pretreatment with the anti-inflammatory agent ibuprofen enhances the effects of AIH | ||
| 520 | |a METHODS: A randomized, double-blinded, placebo-controlled crossover design was used. Nine adults (mean age 51.1 ± 13.1 years) with chronic motor-incomplete SCI (7.7 ± 6.3 years post-injury) received a single dose of ibuprofen (800 mg) or placebo, 90 minutes prior to AIH. For AIH, 9% O2 for 90 seconds was interspersed with 21% O2 for 60 seconds. Maximal voluntary ankle plantar flexion isometric torque was assessed prior to, and at 0, 30, and 60 minutes post-AIH. Surface electromyography (EMG) of plantar flexor muscles was also recorded | ||
| 520 | |a RESULTS: Torque increased significantly after AIH at 30 (P = 0.007; by ∼20%) and 60 (P < 0.001; by ∼30%) minutes post-AIH versus baseline. Ibuprofen did not augment the effects of AIH. EMG activity did not increase significantly after AIH; however, there was a significant association between increases in torque and EMG in both gastrocnemius (R2 = 0.17, P < 0.005) and soleus (R2 = 0.17, P < 0.005) muscles | ||
| 520 | |a CONCLUSIONS: AIH systematically increased lower extremity torque in individuals with chronic incomplete SCI, but there was no significant effect of ibuprofen pretreatment. Our study re-confirms the ability of AIH to enhance leg strength in persons with chronic incomplete SCI | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Hypoxia | |
| 650 | 4 | |a Ibuprofen | |
| 650 | 4 | |a Muscle strength dynamometer | |
| 650 | 4 | |a Neuronal plasticity | |
| 650 | 4 | |a Rehabilitation | |
| 650 | 4 | |a Spinal cord injury | |
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| 700 | 1 | |a Sandhu, Milap |e verfasserin |4 aut | |
| 700 | 1 | |a Srivatsan, Sudarshan |e verfasserin |4 aut | |
| 700 | 1 | |a Deatsch, Kelly |e verfasserin |4 aut | |
| 700 | 1 | |a Kessler, Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Mitchell, Gordon S |e verfasserin |4 aut | |
| 700 | 1 | |a Jayaraman, Arun |e verfasserin |4 aut | |
| 700 | 1 | |a Rymer, William Zev |e verfasserin |4 aut | |
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