Peripheral nervous system involvement in primary burning mouth syndrome--results of a pilot study
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
OBJECTIVE: The pathophysiology of primary burning mouth syndrome (BMS) has remained enigmatic, but recent studies suggest pathology within the nervous system at multiple levels. This study aimed to investigate in detail the contribution of either focal or generalized alterations within the peripheral nervous system (PNS) in the etiopathogenesis of BMS.
SUBJECTS AND METHODS: Intraepithelial nerve fiber density (IENFD) of tongue mucosa was assessed in 10 carefully characterized BMS, and the results were compared to 19 age- and gender-matched cadaver controls, 6 with lifetime diabetes. Extensive neurophysiologic and psychophysical examinations of the trigeminal system and distal extremities were performed to profile PNS function in BMS.
RESULTS: Patients with BMS had significantly fewer intraepithelial nerve fibers (0,27, s.e. 0,18 mm(-1); P = 0.0253) than non-diabetic controls (0,92, s.e. 0,15 mm(-1)). In the subepithelial space, the amount of nerve fibers did not differ between the groups. The majority (9/10) of patients with BMS showed neurophysiologic or psychophysical signs of a more generalized PNS dysfunction.
CONCLUSIONS: Our results in neurophysiologically optimally characterized BMS patients confirm that pure focal small fiber neuropathy of the oral mucosa has a role in the pathophysiology of primary BMS. Furthermore, BMS may be related to a more generalized, yet subclinical peripheral neuropathy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Oral diseases - 22(2016), 4 vom: 05. Mai, Seite 338-44 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Puhakka, A [VerfasserIn] |
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| Links: |
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| Themen: |
Burning mouth syndrome |
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| Anmerkungen: |
Date Completed 03.02.2017 Date Revised 10.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/odi.12454 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM257189408 |
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| 245 | 1 | 0 | |a Peripheral nervous system involvement in primary burning mouth syndrome--results of a pilot study |
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| 500 | |a Date Revised 10.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. | ||
| 520 | |a OBJECTIVE: The pathophysiology of primary burning mouth syndrome (BMS) has remained enigmatic, but recent studies suggest pathology within the nervous system at multiple levels. This study aimed to investigate in detail the contribution of either focal or generalized alterations within the peripheral nervous system (PNS) in the etiopathogenesis of BMS | ||
| 520 | |a SUBJECTS AND METHODS: Intraepithelial nerve fiber density (IENFD) of tongue mucosa was assessed in 10 carefully characterized BMS, and the results were compared to 19 age- and gender-matched cadaver controls, 6 with lifetime diabetes. Extensive neurophysiologic and psychophysical examinations of the trigeminal system and distal extremities were performed to profile PNS function in BMS | ||
| 520 | |a RESULTS: Patients with BMS had significantly fewer intraepithelial nerve fibers (0,27, s.e. 0,18 mm(-1); P = 0.0253) than non-diabetic controls (0,92, s.e. 0,15 mm(-1)). In the subepithelial space, the amount of nerve fibers did not differ between the groups. The majority (9/10) of patients with BMS showed neurophysiologic or psychophysical signs of a more generalized PNS dysfunction | ||
| 520 | |a CONCLUSIONS: Our results in neurophysiologically optimally characterized BMS patients confirm that pure focal small fiber neuropathy of the oral mucosa has a role in the pathophysiology of primary BMS. Furthermore, BMS may be related to a more generalized, yet subclinical peripheral neuropathy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a burning mouth syndrome | |
| 650 | 4 | |a intraepithelial nerve fiber density | |
| 650 | 4 | |a peripheral neuropathy | |
| 650 | 4 | |a small fiber neuropathy | |
| 700 | 1 | |a Forssell, H |e verfasserin |4 aut | |
| 700 | 1 | |a Soinila, S |e verfasserin |4 aut | |
| 700 | 1 | |a Virtanen, A |e verfasserin |4 aut | |
| 700 | 1 | |a Röyttä, M |e verfasserin |4 aut | |
| 700 | 1 | |a Laine, M |e verfasserin |4 aut | |
| 700 | 1 | |a Tenovuo, O |e verfasserin |4 aut | |
| 700 | 1 | |a Teerijoki-Oksa, T |e verfasserin |4 aut | |
| 700 | 1 | |a Jääskeläinen, S K |e verfasserin |4 aut | |
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