Pregnancy as a Window to Future Cardiovascular Health : Design and Implementation of the nuMoM2b Heart Health Study
© The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:183 |
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| Enthalten in: |
American journal of epidemiology - 183(2016), 6 vom: 15. März, Seite 519-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Haas, David M [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular disease |
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| Anmerkungen: |
Date Completed 18.07.2016 Date Revised 02.04.2022 published: Print-Electronic ClinicalTrials.gov: NCT02231398 Citation Status MEDLINE |
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| doi: |
10.1093/aje/kwv309 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM256984166 |
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| 500 | |a ClinicalTrials.gov: NCT02231398 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author 2016. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a The National Institute of Child Health and Human Development's Nulliparous Pregnancy Outcomes Study-Monitoring Mothers-to-Be (nuMoM2b) Heart Health Study (HHS) was designed to investigate the relationships between adverse pregnancy outcomes and modifiable risk factors for cardiovascular disease. The ongoing nuMoM2b-HHS, which started in 2013, is a prospective follow-up of the nuMoM2b cohort, which included 10,038 women recruited between 2010 and 2013 from 8 centers across the United States who were initially observed over the course of their first pregnancies. In this report, we detail the design and study procedures of the nuMoM2b-HHS. Women in the pregnancy cohort who consented to be contacted for participation in future studies were approached at 6-month intervals to ascertain health information and to maintain ongoing contact. Two to 5 years after completion of the pregnancy documented in the nuMoM2b, women in the nuMoM2b-HHS were invited to an in-person study visit. During this visit, they completed psychosocial and medical history questionnaires and had clinical measurements and biological specimens obtained. A subcohort of participants who had objective assessments of sleep-disordered breathing during pregnancy were asked to repeat this investigation. This unique prospective observational study includes a large, geographically and ethnically diverse cohort, rich depth of phenotypic information about adverse pregnancy outcomes, and clinical data and biospecimens from early in the index pregnancy onward. Data obtained from this cohort will provide mechanistic and clinical insights into how data on a first pregnancy can provide information about the potential development of subsequent risk factors for cardiovascular disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a cohort study | |
| 650 | 4 | |a heart health | |
| 650 | 4 | |a methods | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a women's health | |
| 700 | 1 | |a Ehrenthal, Deborah B |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Matthew A |e verfasserin |4 aut | |
| 700 | 1 | |a Catov, Janet M |e verfasserin |4 aut | |
| 700 | 1 | |a Barnes, Shannon E |e verfasserin |4 aut | |
| 700 | 1 | |a Facco, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Parker, Corette B |e verfasserin |4 aut | |
| 700 | 1 | |a Mercer, Brian M |e verfasserin |4 aut | |
| 700 | 1 | |a Bairey-Merz, C Noel |e verfasserin |4 aut | |
| 700 | 1 | |a Silver, Robert M |e verfasserin |4 aut | |
| 700 | 1 | |a Wapner, Ronald J |e verfasserin |4 aut | |
| 700 | 1 | |a Simhan, Hyagriv N |e verfasserin |4 aut | |
| 700 | 1 | |a Hoffman, Matthew K |e verfasserin |4 aut | |
| 700 | 1 | |a Grobman, William A |e verfasserin |4 aut | |
| 700 | 1 | |a Greenland, Philip |e verfasserin |4 aut | |
| 700 | 1 | |a Wing, Deborah A |e verfasserin |4 aut | |
| 700 | 1 | |a Saade, George R |e verfasserin |4 aut | |
| 700 | 1 | |a Parry, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Zee, Phyllis C |e verfasserin |4 aut | |
| 700 | 1 | |a Reddy, Uma M |e verfasserin |4 aut | |
| 700 | 1 | |a Pemberton, Victoria L |e verfasserin |4 aut | |
| 700 | 1 | |a Burwen, Dale R |e verfasserin |4 aut | |
| 700 | 0 | |a National Heart, Lung, and Blood Institute nuMoM2b Heart Health Study Network |e verfasserin |4 aut | |
| 700 | 1 | |a Haas, David M |e investigator |4 oth | |
| 700 | 1 | |a Barnes, Shannon E |e investigator |4 oth | |
| 700 | 1 | |a Ehrenthal, Deborah B |e investigator |4 oth | |
| 700 | 1 | |a Koch, Matthew A |e investigator |4 oth | |
| 700 | 1 | |a Parker, Corette B |e investigator |4 oth | |
| 700 | 1 | |a Catov, Janet M |e investigator |4 oth | |
| 700 | 1 | |a Facco, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Simhan, Hyagriv N |e investigator |4 oth | |
| 700 | 1 | |a Mercer, Brian M |e investigator |4 oth | |
| 700 | 1 | |a Noel Bairey-Merz, C |e investigator |4 oth | |
| 700 | 1 | |a Silver, Robert M |e investigator |4 oth | |
| 700 | 1 | |a Wapner, Ronald J |e investigator |4 oth | |
| 700 | 1 | |a Hoffman, Matthew K |e investigator |4 oth | |
| 700 | 1 | |a Grobman, William A |e investigator |4 oth | |
| 700 | 1 | |a Greenland, Philip |e investigator |4 oth | |
| 700 | 1 | |a Wing, Deborah A |e investigator |4 oth | |
| 700 | 1 | |a Saade, George R |e investigator |4 oth | |
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| 700 | 1 | |a Zee, Phyllis C |e investigator |4 oth | |
| 700 | 1 | |a Reddy, Uma M |e investigator |4 oth | |
| 700 | 1 | |a Pemberton, Victoria L |e investigator |4 oth | |
| 700 | 1 | |a Burwen, Dale R |e investigator |4 oth | |
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