Analysis of clinical relevant bleeding events in the elderly patients with acute pulmonary thromboembolism after treatment
OBJECTIVE: To investigate the incidences of clinical relevant bleeding events and risk factors in elderly patients with acute pulmonary thromboembolism (PTE).
METHODS: Between January of 2009 and December of 2013, a total of 539 initially diagnosed PTE patients were recruited in our study in Beijing Chao Yang hospital. Basic clinical characteristics, medical history, imaging results, laboratory tests, therapy and outcomes (including mortality, recurrence and incidences of bleeding events) were collected during 3 months' follow-up. All the patients were divided into two groups according to age (≤ 65 years and >65 years ), and these parameters were compared between the two groups.
RESULTS: Compared with younger patients (≤ 65 years old), older patients (>65 years) had higher incidences of total bleeding, clinical relevant non-major bleeding (20.2% vs 13.4%, P=0.038; 16.7% vs 10.5%, P=0.043). The incidence of gastrointestinal bleeding of the elderly was also higher than that of younger patients (6.0% vs 1.4%, P=0.005) and majority of bleeding events were within 1 month after initial treatment. For the elderly, chronic liver diseases (P=0.001, OR=9.229), ischemic stroke (P=0.001, OR=6.323) and anemia (P=0.014, OR=3.774) were independent risk factors for major bleeding, and malignancy (P<0.001, OR=3.140) was independent risk factor for clinical relevant non-major bleeding. The independent risk factors for gastrointestinal bleeding were diabetes mellitus (P=0.012, OR=3.711) and anemia (P<0.001, OR=5.863).
CONCLUSIONS: The older PTE patients had higher incidences of total bleeding and clinical relevant non-major bleeding. Gastrointestinal bleeding of the elderly was also higher than that of younger patients and mainly occurred within 1 month after initial treatment. Complications can increase the risk of bleeding in older PTE patients.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
|---|---|
| Enthalten in: |
Zhonghua yi xue za zhi - 95(2015), 44 vom: 24. Nov., Seite 3588-92 |
| Sprache: |
Chinesisch |
|---|
| Beteiligte Personen: |
Gong, Juanni [VerfasserIn] |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 26.04.2016 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM256861641 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM256861641 | ||
| 003 | DE-627 | ||
| 005 | 20231224181557.0 | ||
| 007 | tu | ||
| 008 | 231224s2015 xx ||||| 00| ||chi c | ||
| 028 | 5 | 2 | |a pubmed24n0856.xml |
| 035 | |a (DE-627)NLM256861641 | ||
| 035 | |a (NLM)26813370 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a chi | ||
| 100 | 1 | |a Gong, Juanni |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Analysis of clinical relevant bleeding events in the elderly patients with acute pulmonary thromboembolism after treatment |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 26.04.2016 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the incidences of clinical relevant bleeding events and risk factors in elderly patients with acute pulmonary thromboembolism (PTE) | ||
| 520 | |a METHODS: Between January of 2009 and December of 2013, a total of 539 initially diagnosed PTE patients were recruited in our study in Beijing Chao Yang hospital. Basic clinical characteristics, medical history, imaging results, laboratory tests, therapy and outcomes (including mortality, recurrence and incidences of bleeding events) were collected during 3 months' follow-up. All the patients were divided into two groups according to age (≤ 65 years and >65 years ), and these parameters were compared between the two groups | ||
| 520 | |a RESULTS: Compared with younger patients (≤ 65 years old), older patients (>65 years) had higher incidences of total bleeding, clinical relevant non-major bleeding (20.2% vs 13.4%, P=0.038; 16.7% vs 10.5%, P=0.043). The incidence of gastrointestinal bleeding of the elderly was also higher than that of younger patients (6.0% vs 1.4%, P=0.005) and majority of bleeding events were within 1 month after initial treatment. For the elderly, chronic liver diseases (P=0.001, OR=9.229), ischemic stroke (P=0.001, OR=6.323) and anemia (P=0.014, OR=3.774) were independent risk factors for major bleeding, and malignancy (P<0.001, OR=3.140) was independent risk factor for clinical relevant non-major bleeding. The independent risk factors for gastrointestinal bleeding were diabetes mellitus (P=0.012, OR=3.711) and anemia (P<0.001, OR=5.863) | ||
| 520 | |a CONCLUSIONS: The older PTE patients had higher incidences of total bleeding and clinical relevant non-major bleeding. Gastrointestinal bleeding of the elderly was also higher than that of younger patients and mainly occurred within 1 month after initial treatment. Complications can increase the risk of bleeding in older PTE patients | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Zhai, Zhenguo |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yuanhua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Zhu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Shuai |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Wanmu |e verfasserin |4 aut | |
| 700 | 1 | |a Kuang, Tuguang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chen |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zhonghua yi xue za zhi |d 1994 |g 95(2015), 44 vom: 24. Nov., Seite 3588-92 |w (DE-627)NLM000566861 |x 0376-2491 |7 nnns |
| 773 | 1 | 8 | |g volume:95 |g year:2015 |g number:44 |g day:24 |g month:11 |g pages:3588-92 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 95 |j 2015 |e 44 |b 24 |c 11 |h 3588-92 | ||