Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models
Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
|---|---|
| Enthalten in: |
Scientific reports - 6(2016) vom: 18. Jan., Seite 19399 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Miquel, S [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 26.12.2016 Date Revised 13.11.2018 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/srep19399 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM256529213 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM256529213 | ||
| 003 | DE-627 | ||
| 005 | 20231226192509.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/srep19399 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0855.xml |
| 035 | |a (DE-627)NLM256529213 | ||
| 035 | |a (NLM)26775847 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Miquel, S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.12.2016 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Martín, R |e verfasserin |4 aut | |
| 700 | 1 | |a Lashermes, A |e verfasserin |4 aut | |
| 700 | 1 | |a Gillet, M |e verfasserin |4 aut | |
| 700 | 1 | |a Meleine, M |e verfasserin |4 aut | |
| 700 | 1 | |a Gelot, A |e verfasserin |4 aut | |
| 700 | 1 | |a Eschalier, A |e verfasserin |4 aut | |
| 700 | 1 | |a Ardid, D |e verfasserin |4 aut | |
| 700 | 1 | |a Bermúdez-Humarán, L G |e verfasserin |4 aut | |
| 700 | 1 | |a Sokol, H |e verfasserin |4 aut | |
| 700 | 1 | |a Thomas, M |e verfasserin |4 aut | |
| 700 | 1 | |a Theodorou, V |e verfasserin |4 aut | |
| 700 | 1 | |a Langella, P |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, F A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d 2011 |g 6(2016) vom: 18. Jan., Seite 19399 |w (DE-627)NLM215703936 |x 2045-2322 |7 nnns |
| 773 | 1 | 8 | |g volume:6 |g year:2016 |g day:18 |g month:01 |g pages:19399 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/srep19399 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 6 |j 2016 |b 18 |c 01 |h 19399 | ||