FSH and FSHR gene polymorphisms and male infertility : An update
Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Zhonghua nan ke xue = National journal of andrology - 21(2015), 11 vom: 05. Nov., Seite 1031-4 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Wu, Qiu-yue [VerfasserIn] |
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| Themen: |
9002-68-0 |
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| Anmerkungen: |
Date Completed 02.02.2016 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM256206031 |
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| 100 | 1 | |a Wu, Qiu-yue |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a FSH and FSHR gene polymorphisms and male infertility |b An update |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Follicle-stimulating hormone (FSH) is synthesized and secreted by the anterior pituitary, which binds to its receptors expressed on the membrane of Sertoli cells in the testis to bring about spermatogenesis. With the development of DNA sequencing technology, FSH SNPs rs10835638 and FSHR SNPs rs6165, rs6166, and rs1394205 were detected, which might directly affect the expression of FSH and activity of FSHR, resulting in male spermatogenic dysfunction. This review focuses on the relationship of FSH and FSHR gene polymorphisms with male infertility | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Receptors, FSH |2 NLM | |
| 650 | 7 | |a Follicle Stimulating Hormone |2 NLM | |
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| 700 | 1 | |a Xia, Xin-yi |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yu-feng |e verfasserin |4 aut | |
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