Calcium sensitivity in vascular smooth muscle cell during hypoxic pulmonary vasoconstriction
Hypoxic pulmonary vasoconstriction is a means of optimising the oxygenation of blood in the lungs by redistributing the flow from poorly ventilated areas into well ventilated ones. It is caused by a direct effect of hypoxia on pulmonary vascular smooth muscle cells. For a vascular smooth muscle cell to contract, an increased intracellular concentration of calcium is needed. However, the contraction force can also be regulated independently of calcium concentration by calcium sensitivity. The sensitivity is regulated mainly by activation/deactivation of myosin light chain phosphatase. Several metabolic pathways converge on this enzyme. The increase in calcium sensitivity is an important process during hypoxic pulmonary vasoconstriction.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Ceskoslovenska fysiologie - 64(2015), 1 vom: 05., Seite 19-22 |
| Sprache: |
Tschechisch |
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| Weiterer Titel: |
Senzitivita cévní hladké svalové bunky k vápníku pri hypoxické plicní vazokonstrikci |
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| Beteiligte Personen: |
Koubský, K [VerfasserIn] |
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| Themen: |
Calcium |
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| Anmerkungen: |
Date Completed 13.12.2016 Date Revised 30.12.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM256205140 |
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| 520 | |a Hypoxic pulmonary vasoconstriction is a means of optimising the oxygenation of blood in the lungs by redistributing the flow from poorly ventilated areas into well ventilated ones. It is caused by a direct effect of hypoxia on pulmonary vascular smooth muscle cells. For a vascular smooth muscle cell to contract, an increased intracellular concentration of calcium is needed. However, the contraction force can also be regulated independently of calcium concentration by calcium sensitivity. The sensitivity is regulated mainly by activation/deactivation of myosin light chain phosphatase. Several metabolic pathways converge on this enzyme. The increase in calcium sensitivity is an important process during hypoxic pulmonary vasoconstriction | ||
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