Infection status and prognostic significance analysis of Epstein-Barr virus in 207 cases with newly diagnosed Hodgkin's lymphoma
OBJECTIVE: To evaluate the Epstein Barr virus (EBV) positive rate in untreated Hodgkin's lymphoma (HL) and investigate the prognostic significance of EBV status.
METHODS: A total of 207 previously untreated patients with histologically confirmed Hodgkin's lymphoma were enrolled in the study. The EBV infection status was confirmed through examining EBV-RNA (EBER) or EBV latent membrane protein-1. The correlation of clinical features and EBV infection status was analyzed, also the prognostic significance of EBV infection.
RESULTS: A total of 66 cases were confirmed to be EBV positive Hodgkin's lymphoma (EBV⁺ HL) in all 207 cases, accounting for 31.9%. EBV⁺ HL group had more male patients (46/66, 69.7%) and mixed cellularity subtype (34/66, 51.5%) than EBV negative Hodgkin's lymphoma (EBV⁻ HL) group. The EBV positive rate had two peaks in age, respectively, in the age of 0-15 yeaR-old and >60 yeaR-old. During a median follow-up period of 35 months, EBV⁻ HL was significant better than EBV⁺ HL in overall survival (P=0.001), but no significant difference was found in progression-free survival (P=0.763).
CONCLUSION: EBV positive is a poor prognostic factor for overall survival time in HL.
Medienart: |
Artikel |
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Erscheinungsjahr: |
2015 |
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Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
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Enthalten in: |
Zhonghua yi xue za zhi - 95(2015), 32 vom: 25. Aug., Seite 2594-8 |
Sprache: |
Chinesisch |
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Beteiligte Personen: |
Kang, Suyi [VerfasserIn] |
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Themen: |
EBV-associated membrane antigen, Epstein-Barr virus |
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Anmerkungen: |
Date Completed 30.03.2016 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM255967349 |
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245 | 1 | 0 | |a Infection status and prognostic significance analysis of Epstein-Barr virus in 207 cases with newly diagnosed Hodgkin's lymphoma |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Completed 30.03.2016 | ||
500 | |a Date Revised 02.12.2018 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a OBJECTIVE: To evaluate the Epstein Barr virus (EBV) positive rate in untreated Hodgkin's lymphoma (HL) and investigate the prognostic significance of EBV status | ||
520 | |a METHODS: A total of 207 previously untreated patients with histologically confirmed Hodgkin's lymphoma were enrolled in the study. The EBV infection status was confirmed through examining EBV-RNA (EBER) or EBV latent membrane protein-1. The correlation of clinical features and EBV infection status was analyzed, also the prognostic significance of EBV infection | ||
520 | |a RESULTS: A total of 66 cases were confirmed to be EBV positive Hodgkin's lymphoma (EBV⁺ HL) in all 207 cases, accounting for 31.9%. EBV⁺ HL group had more male patients (46/66, 69.7%) and mixed cellularity subtype (34/66, 51.5%) than EBV negative Hodgkin's lymphoma (EBV⁻ HL) group. The EBV positive rate had two peaks in age, respectively, in the age of 0-15 yeaR-old and >60 yeaR-old. During a median follow-up period of 35 months, EBV⁻ HL was significant better than EBV⁺ HL in overall survival (P=0.001), but no significant difference was found in progression-free survival (P=0.763) | ||
520 | |a CONCLUSION: EBV positive is a poor prognostic factor for overall survival time in HL | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a EBV-associated membrane antigen, Epstein-Barr virus |2 NLM | |
650 | 7 | |a RNA, Viral |2 NLM | |
650 | 7 | |a Viral Matrix Proteins |2 NLM | |
700 | 1 | |a Qin, Yan |e verfasserin |4 aut | |
700 | 1 | |a He, Xiaohui |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Shengyu |e verfasserin |4 aut | |
700 | 1 | |a Han, Xiaohong |e verfasserin |4 aut | |
700 | 1 | |a Liu, Peng |e verfasserin |4 aut | |
700 | 1 | |a Dong, Mei |e verfasserin |4 aut | |
700 | 1 | |a Zhou, Liqiang |e verfasserin |4 aut | |
700 | 1 | |a Yang, Jianliang |e verfasserin |4 aut | |
700 | 1 | |a Yang, Sheng |e verfasserin |4 aut | |
700 | 1 | |a Zhang, Changgong |e verfasserin |4 aut | |
700 | 1 | |a Gui, Lin |e verfasserin |4 aut | |
700 | 1 | |a Shi, Yuankai |e verfasserin |4 aut | |
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