Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp(3))-C(sp(2)) Bonds : Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes
A transition-metal-free deacylative C(sp(3))-C(sp(2)) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and commercially abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Organic letters - 18(2016), 2 vom: 15. Jan., Seite 228-31 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ge, Jing-Jie [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 23.05.2016 Date Revised 15.01.2016 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.5b03367 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM255905149 |
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| 245 | 1 | 0 | |a Transition-Metal-Free Deacylative Cleavage of Unstrained C(sp(3))-C(sp(2)) Bonds |b Cyanide-Free Access to Aryl and Aliphatic Nitriles from Ketones and Aldehydes |
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| 500 | |a Date Completed 23.05.2016 | ||
| 500 | |a Date Revised 15.01.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A transition-metal-free deacylative C(sp(3))-C(sp(2)) bond cleavage for the synthetically practical oxidative amination of ketones and aldehydes to nitriles is first described, using cheap and commercially abundant NaNO2 as the oxidant and the nitrogen source. Various nitriles bearing aryl, heteroaryl, alkyl, and alkenyl groups could be smoothly obtained from ketones and aldehydes in high yields, avoiding highly toxic cyanides or transition metals | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Yao, Chuan-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Mei-Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Hong-Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Kang, Yan-Biao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yadong |e verfasserin |4 aut | |
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