The Microbiome, Systemic Immune Function, and Allotransplantation
Copyright © 2015, American Society for Microbiology. All Rights Reserved..
Diverse effects of the microbiome on solid organ transplantation are beginning to be recognized. In allograft recipients, microbial networks are disrupted by immunosuppression, nosocomial and community-based infectious exposures, antimicrobial therapies, surgery, and immune processes. Shifting microbial patterns, including acute infectious exposures, have dynamic and reciprocal interactions with local and systemic immune systems. Both individual microbial species and microbial networks have central roles in the induction and control of innate and adaptive immune responses, in graft rejection, and in ischemia-reperfusion injury. Understanding the diverse interactions between the microbiome and the immune system of allograft recipients may facilitate clinical management in the future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Clinical microbiology reviews - 29(2016), 1 vom: 10. Jan., Seite 191-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nellore, Anoma [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 02.08.2016 Date Revised 03.12.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1128/CMR.00063-15 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM255464479 |
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| 520 | |a Diverse effects of the microbiome on solid organ transplantation are beginning to be recognized. In allograft recipients, microbial networks are disrupted by immunosuppression, nosocomial and community-based infectious exposures, antimicrobial therapies, surgery, and immune processes. Shifting microbial patterns, including acute infectious exposures, have dynamic and reciprocal interactions with local and systemic immune systems. Both individual microbial species and microbial networks have central roles in the induction and control of innate and adaptive immune responses, in graft rejection, and in ischemia-reperfusion injury. Understanding the diverse interactions between the microbiome and the immune system of allograft recipients may facilitate clinical management in the future | ||
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