Correlation between cardio-pulmonary exercise test variables and health-related quality of life among children with congenital heart diseases
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved..
BACKGROUND: Health-related quality of life (HR-QoL) stands as a determinant "patient-related outcome" and correlates with cardio-pulmonary exercise test (CPET) in adults with chronic heart failure or with a congenital heart disease (CHD). No such correlation has been established in pediatric cardiology.
METHODS AND RESULTS: 202 CHD children aged 8 to 18 performed a CPET (treadmill n=96, cycle-ergometer n=106). CHD severity was stratified into 4 groups. All children and parents filled out the Kidscreen HR-QoL questionnaire. Peak VO2, anaerobic threshold (AT), and oxygen pulse followed a downward significant trend with increasing CHD severity and conversely for VE/VCO2 slope. Self-reported and parent-reported physical well-being HR-QoL scores correlated with peak VO2 (respectively r=0.27, p<0.0001 and r=0.43, p<0.0001), percentage of predicted peak VO2 (r=0.28, p=0.0001 and r=0.41, p<0.0001), and percentage of predicted VO2 at AT (r=0.22, p<0.01 and r=0.31, p<0.0001). Significant correlations were also observed between several HR-QoL dimensions and dead space to tidal volume ratio (VD/VT), oxygen uptake efficiency slope (OUES), oxygen pulse but never with VE/VCO2 slope. The strongest correlations were observed in the treadmill group, especially between peak VO2 and physical well-being for parents (r=0.57, p<0.0001) and self (r=0.40, p<0.0001) reported HR-QoL.
CONCLUSIONS: Peak VO2 and AT are the two CPET variables that best correlated with HR-QoL in this large pediatric cohort, parents' reports being more accurate. If HR-QoL is involved as a "PRO" in a pediatric cardiology clinical trial, we suggest using parents related physical well-being HR-QoL scores.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (number NCT01202916).
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
|---|---|
| Enthalten in: |
International journal of cardiology - 203(2016) vom: 15. Jan., Seite 1052-60 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Amedro, P [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Cardio-pulmonary exercise test |
|---|
| Anmerkungen: |
Date Completed 01.11.2016 Date Revised 30.12.2016 published: Print-Electronic ClinicalTrials.gov: NCT01202916 Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijcard.2015.11.028 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM255296770 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM255296770 | ||
| 003 | DE-627 | ||
| 005 | 20231224174212.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijcard.2015.11.028 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0851.xml |
| 035 | |a (DE-627)NLM255296770 | ||
| 035 | |a (NLM)26638054 | ||
| 035 | |a (PII)S0167-5273(15)30837-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Amedro, P |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Correlation between cardio-pulmonary exercise test variables and health-related quality of life among children with congenital heart diseases |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.11.2016 | ||
| 500 | |a Date Revised 30.12.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT01202916 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Health-related quality of life (HR-QoL) stands as a determinant "patient-related outcome" and correlates with cardio-pulmonary exercise test (CPET) in adults with chronic heart failure or with a congenital heart disease (CHD). No such correlation has been established in pediatric cardiology | ||
| 520 | |a METHODS AND RESULTS: 202 CHD children aged 8 to 18 performed a CPET (treadmill n=96, cycle-ergometer n=106). CHD severity was stratified into 4 groups. All children and parents filled out the Kidscreen HR-QoL questionnaire. Peak VO2, anaerobic threshold (AT), and oxygen pulse followed a downward significant trend with increasing CHD severity and conversely for VE/VCO2 slope. Self-reported and parent-reported physical well-being HR-QoL scores correlated with peak VO2 (respectively r=0.27, p<0.0001 and r=0.43, p<0.0001), percentage of predicted peak VO2 (r=0.28, p=0.0001 and r=0.41, p<0.0001), and percentage of predicted VO2 at AT (r=0.22, p<0.01 and r=0.31, p<0.0001). Significant correlations were also observed between several HR-QoL dimensions and dead space to tidal volume ratio (VD/VT), oxygen uptake efficiency slope (OUES), oxygen pulse but never with VE/VCO2 slope. The strongest correlations were observed in the treadmill group, especially between peak VO2 and physical well-being for parents (r=0.57, p<0.0001) and self (r=0.40, p<0.0001) reported HR-QoL | ||
| 520 | |a CONCLUSIONS: Peak VO2 and AT are the two CPET variables that best correlated with HR-QoL in this large pediatric cohort, parents' reports being more accurate. If HR-QoL is involved as a "PRO" in a pediatric cardiology clinical trial, we suggest using parents related physical well-being HR-QoL scores | ||
| 520 | |a CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (number NCT01202916) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cardio-pulmonary exercise test | |
| 650 | 4 | |a Congenital heart disease | |
| 650 | 4 | |a Peak VO2 | |
| 650 | 4 | |a Pediatrics | |
| 650 | 4 | |a Quality of life | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 700 | 1 | |a Picot, M C |e verfasserin |4 aut | |
| 700 | 1 | |a Moniotte, S |e verfasserin |4 aut | |
| 700 | 1 | |a Dorka, R |e verfasserin |4 aut | |
| 700 | 1 | |a Bertet, H |e verfasserin |4 aut | |
| 700 | 1 | |a Guillaumont, S |e verfasserin |4 aut | |
| 700 | 1 | |a Barrea, C |e verfasserin |4 aut | |
| 700 | 1 | |a Vincenti, M |e verfasserin |4 aut | |
| 700 | 1 | |a De La Villeon, G |e verfasserin |4 aut | |
| 700 | 1 | |a Bredy, C |e verfasserin |4 aut | |
| 700 | 1 | |a Soulatges, C |e verfasserin |4 aut | |
| 700 | 1 | |a Voisin, M |e verfasserin |4 aut | |
| 700 | 1 | |a Matecki, S |e verfasserin |4 aut | |
| 700 | 1 | |a Auquier, P |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d 1984 |g 203(2016) vom: 15. Jan., Seite 1052-60 |w (DE-627)NLM012621196 |x 1874-1754 |7 nnns |
| 773 | 1 | 8 | |g volume:203 |g year:2016 |g day:15 |g month:01 |g pages:1052-60 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijcard.2015.11.028 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 203 |j 2016 |b 15 |c 01 |h 1052-60 | ||