Quantitative Electroencephalography as a Diagnostic Tool for Alzheimer's Dementia in Adults with Down Syndrome
BACKGROUND: Assessment of dementia in individuals with intellectual disability is complex due to great inter-individual variability in cognitive function prior to dementia and a lack of standardized instruments. Studies have indicated that quantitative electroencephalography (qEEG) results may be used as a diagnostic marker for dementia. The aim of this study was to examine the value of qEEG in the diagnostic evaluation of dementia in patients with Down syndrome (DS).
METHOD: The study included 21 patients with DS and mild-to-moderate dementia due to Alzheimer's disease (DS-AD) and 16 age-matched adults with DS without cognitive deterioration assessed by the informant-based Dementia Screening Questionnaire in Intellectual Disability (DSQIID). Conventional EEG was performed and analysed quantitatively using fast Fourier transformation. Outcomes were centroid frequency, peak frequency, absolute power, and relative power.
RESULTS: In several regions of the brain, a significant decrease in the theta-1 band (4-7 Hz) was identified for the centroid frequency. A significant negative correlation was demonstrated between the mean of the centroid frequency of the theta-1 band and the total DSQIID score.
CONCLUSION: We found that qEEG can detect a significant decrease in centroid frequency in a sample of patients with DS-AD as compared to a sample of adults with DS and no cognitive deterioration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Dementia and geriatric cognitive disorders extra - 5(2015), 3 vom: 01. Sept., Seite 404-13 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salem, Lise Cronberg [VerfasserIn] |
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| Links: |
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| Themen: |
Alzheimer's dementia |
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| Anmerkungen: |
Date Completed 02.12.2015 Date Revised 29.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1159/000438857 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM255210566 |
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| 100 | 1 | |a Salem, Lise Cronberg |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Quantitative Electroencephalography as a Diagnostic Tool for Alzheimer's Dementia in Adults with Down Syndrome |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 02.12.2015 | ||
| 500 | |a Date Revised 29.09.2020 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Assessment of dementia in individuals with intellectual disability is complex due to great inter-individual variability in cognitive function prior to dementia and a lack of standardized instruments. Studies have indicated that quantitative electroencephalography (qEEG) results may be used as a diagnostic marker for dementia. The aim of this study was to examine the value of qEEG in the diagnostic evaluation of dementia in patients with Down syndrome (DS) | ||
| 520 | |a METHOD: The study included 21 patients with DS and mild-to-moderate dementia due to Alzheimer's disease (DS-AD) and 16 age-matched adults with DS without cognitive deterioration assessed by the informant-based Dementia Screening Questionnaire in Intellectual Disability (DSQIID). Conventional EEG was performed and analysed quantitatively using fast Fourier transformation. Outcomes were centroid frequency, peak frequency, absolute power, and relative power | ||
| 520 | |a RESULTS: In several regions of the brain, a significant decrease in the theta-1 band (4-7 Hz) was identified for the centroid frequency. A significant negative correlation was demonstrated between the mean of the centroid frequency of the theta-1 band and the total DSQIID score | ||
| 520 | |a CONCLUSION: We found that qEEG can detect a significant decrease in centroid frequency in a sample of patients with DS-AD as compared to a sample of adults with DS and no cognitive deterioration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Alzheimer's dementia | |
| 650 | 4 | |a Diagnostic assessment | |
| 650 | 4 | |a Down syndrome | |
| 650 | 4 | |a Quantitative electroencephalography | |
| 700 | 1 | |a Sabers, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Kjaer, Troels W |e verfasserin |4 aut | |
| 700 | 1 | |a Musaeus, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Martin N |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, Anne-Grete |e verfasserin |4 aut | |
| 700 | 1 | |a Waldemar, Gunhild |e verfasserin |4 aut | |
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