Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection : A population-based analysis
Copyright © 2015 Elsevier Ltd. All rights reserved..
BACKGROUND: This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)).
METHODS: Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated.
RESULTS: The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24).
CONCLUSIONS: Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Vaccine - 34(2016), 1 vom: 02. Jan., Seite 120-7 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Su, Fu-Hsiung [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Hepatitis B virus |
|---|
| Anmerkungen: |
Date Completed 14.11.2016 Date Revised 30.12.2016 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.vaccine.2015.10.129 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM255072961 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM255072961 | ||
| 003 | DE-627 | ||
| 005 | 20231224173731.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.vaccine.2015.10.129 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0850.xml |
| 035 | |a (DE-627)NLM255072961 | ||
| 035 | |a (NLM)26614589 | ||
| 035 | |a (PII)S0264-410X(15)01585-6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Su, Fu-Hsiung |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection |b A population-based analysis |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.11.2016 | ||
| 500 | |a Date Revised 30.12.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)) | ||
| 520 | |a METHODS: Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated | ||
| 520 | |a RESULTS: The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24) | ||
| 520 | |a CONCLUSIONS: Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Hepatitis B virus | |
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Population-based study | |
| 650 | 4 | |a Vaccination | |
| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Huang, Ya-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Sung, Fung-Chang |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Chien-Tien |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Wen-Hsin |e verfasserin |4 aut | |
| 700 | 1 | |a Chang, Shih-Ni |e verfasserin |4 aut | |
| 700 | 1 | |a Yeh, Chih-Ching |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Vaccine |d 1985 |g 34(2016), 1 vom: 02. Jan., Seite 120-7 |w (DE-627)NLM012600105 |x 1873-2518 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2016 |g number:1 |g day:02 |g month:01 |g pages:120-7 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.vaccine.2015.10.129 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2016 |e 1 |b 02 |c 01 |h 120-7 | ||