A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the TNFα-induced invasive capability of MDA-MB-231 human breast cancer cells by inhibiting NF-κB-mediated GROα expression
Copyright © 2015 Elsevier Ltd. All rights reserved..
2-Hydroxy-3',5,5'-trimenthoxyochalcone (DK-139) is a synthetic chalcone-derived compound. This study evaluated the biological activity of DK-139 on the inhibition of tumor metastasis. Growth-regulated oncogene-alpha (GROα) plays an important role in the progression of tumor development by stimulating angiogenesis and metastasis. In this study, DK-139 inhibited tumor necrosis factor alpha (TNFα)-induced GROα gene promoter activity by inhibiting of IκB kinase (IKK) in MDA-MB231 cells. In addition, DK-139 prevented the TNFα-induced cell migration, F-actin formation, and invasive capability of MDA-MB-231 cells. These findings suggest that DK-139 is a potential drug candidate for the inhibition of tumor cell locomotion and invasion via the suppression of NF-κB-mediated GROα expression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 26(2016), 1 vom: 01. Jan., Seite 203-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Da Young [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 26.07.2016 Date Revised 05.05.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2015.10.094 |
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NLM254953948 |
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| 245 | 1 | 2 | |a A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the TNFα-induced invasive capability of MDA-MB-231 human breast cancer cells by inhibiting NF-κB-mediated GROα expression |
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| 520 | |a 2-Hydroxy-3',5,5'-trimenthoxyochalcone (DK-139) is a synthetic chalcone-derived compound. This study evaluated the biological activity of DK-139 on the inhibition of tumor metastasis. Growth-regulated oncogene-alpha (GROα) plays an important role in the progression of tumor development by stimulating angiogenesis and metastasis. In this study, DK-139 inhibited tumor necrosis factor alpha (TNFα)-induced GROα gene promoter activity by inhibiting of IκB kinase (IKK) in MDA-MB231 cells. In addition, DK-139 prevented the TNFα-induced cell migration, F-actin formation, and invasive capability of MDA-MB-231 cells. These findings suggest that DK-139 is a potential drug candidate for the inhibition of tumor cell locomotion and invasion via the suppression of NF-κB-mediated GROα expression | ||
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| 650 | 4 | |a 2-Hydroxy-3′,5,5′-trimenthoxyochalcone | |
| 650 | 4 | |a Growth-regulated oncogene-alpha | |
| 650 | 4 | |a Human breast cancer | |
| 650 | 4 | |a Invasion | |
| 650 | 4 | |a IκB kinase | |
| 650 | 4 | |a Tumor necrosis factor alpha | |
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| 700 | 1 | |a Lee, Da Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Jung, Jung You |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Dongsoo |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Geum-Soog |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Young-Sup |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Young Han |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Yoongho |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Soon Young |e verfasserin |4 aut | |
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