An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents
Copyright © 2015 Elsevier Ltd. All rights reserved..
We have demonstrated a novel and green approach for the synthesis of 2-substituted benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were synthesized using Amberlite IR-120 resin under microwave irradiation. The catalytic role and reusability of the resin was well established here. 2-Substituted benzothiazole analogues (3a-l) were also tested against several bacterial strains (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella) and cancer cell lines (MCF-7 and HeLa). The stability of compound 2-phenyl benzothiazole (3a) and 2-pyridin-2-yl-benzothiazole (3k) in GSH (0.01mM dissolved in DMSO) was measured by UV-Vis spectroscopy. Compound 3k also shows remarkable fluorescence in MeOH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Bioorganic & medicinal chemistry letters - 26(2016), 1 vom: 01. Jan., Seite 213-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chhabra, Mohit [VerfasserIn] |
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| Links: |
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| Themen: |
2-Arylbenzothiazole |
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| Anmerkungen: |
Date Completed 26.07.2016 Date Revised 18.12.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bmcl.2015.10.087 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM254835678 |
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| 245 | 1 | 3 | |a An efficient green synthesis of 2-arylbenzothiazole analogues as potent antibacterial and anticancer agents |
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| 500 | |a Date Revised 18.12.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 520 | |a We have demonstrated a novel and green approach for the synthesis of 2-substituted benzothiazole analogues. A number of 2-aryl and heteroaryl benzothiazole scaffolds were synthesized using Amberlite IR-120 resin under microwave irradiation. The catalytic role and reusability of the resin was well established here. 2-Substituted benzothiazole analogues (3a-l) were also tested against several bacterial strains (Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella) and cancer cell lines (MCF-7 and HeLa). The stability of compound 2-phenyl benzothiazole (3a) and 2-pyridin-2-yl-benzothiazole (3k) in GSH (0.01mM dissolved in DMSO) was measured by UV-Vis spectroscopy. Compound 3k also shows remarkable fluorescence in MeOH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a 2-Arylbenzothiazole | |
| 650 | 4 | |a Amberlite IR-120 | |
| 650 | 4 | |a Antibacterial agents | |
| 650 | 4 | |a Anticancer agents | |
| 650 | 4 | |a Green chemistry | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Benzothiazoles |2 NLM | |
| 700 | 1 | |a Sinha, Sohini |e verfasserin |4 aut | |
| 700 | 1 | |a Banerjee, Swagata |e verfasserin |4 aut | |
| 700 | 1 | |a Paira, Priyankar |e verfasserin |4 aut | |
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