Cardiac GR and MR : From Development to Pathology
Copyright © 2015 Elsevier Ltd. All rights reserved..
The efficacy of mineralocorticoid receptor (MR) antagonism in the treatment of certain patients with heart failure has highlighted the pivotal role of aldosterone and MR in heart disease. The glucocorticoid (GC) receptor (GR) is also expressed in heart, but the role of cardiac GR had received much less attention until recently. GR and MR are highly homologous in both structure and function, although not in cellular readout. Recent evidence in animal models has uncovered a tonic role for GC action via GR in cardiomyocytes in prevention of heart disease. Here, we review this evidence and the implications for a balance between GR and MR activation in the early life maturation of the heart and its subsequent health and disease.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Trends in endocrinology and metabolism: TEM - 27(2016), 1 vom: 04. Jan., Seite 35-43 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Richardson, Rachel V [VerfasserIn] |
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| Links: |
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| Themen: |
11β-HSD |
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| Anmerkungen: |
Date Completed 30.09.2016 Date Revised 02.03.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.tem.2015.10.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM254795560 |
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| 245 | 1 | 0 | |a Cardiac GR and MR |b From Development to Pathology |
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| 500 | |a Date Revised 02.03.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 520 | |a The efficacy of mineralocorticoid receptor (MR) antagonism in the treatment of certain patients with heart failure has highlighted the pivotal role of aldosterone and MR in heart disease. The glucocorticoid (GC) receptor (GR) is also expressed in heart, but the role of cardiac GR had received much less attention until recently. GR and MR are highly homologous in both structure and function, although not in cellular readout. Recent evidence in animal models has uncovered a tonic role for GC action via GR in cardiomyocytes in prevention of heart disease. Here, we review this evidence and the implications for a balance between GR and MR activation in the early life maturation of the heart and its subsequent health and disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a 11β-HSD | |
| 650 | 4 | |a Corticosteroids | |
| 650 | 4 | |a glucocorticoid receptor | |
| 650 | 4 | |a heart | |
| 650 | 4 | |a mineralocorticoid receptor | |
| 650 | 7 | |a Receptors, Glucocorticoid |2 NLM | |
| 650 | 7 | |a Receptors, Mineralocorticoid |2 NLM | |
| 700 | 1 | |a Batchen, Emma J |e verfasserin |4 aut | |
| 700 | 1 | |a Denvir, Martin A |e verfasserin |4 aut | |
| 700 | 1 | |a Gray, Gillian A |e verfasserin |4 aut | |
| 700 | 1 | |a Chapman, Karen E |e verfasserin |4 aut | |
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