Methotrexate may be a useful corticosteroid reducing treatment of severe asthma
Asthma is a chronic airway disease affecting many people worldwide. Less than 1% suffers from difficult-to-treat asthma and requires systemic corticosteroid treatment to achieve symptom control. The therapeutic options for these patients are limited and often we have to accept a lesser degree of symptom control. Methotrexate has been evaluated in 13 studies, where the mean corticosteroid dose reduction was 35%. Despite the adverse effects, we find that methotrexate may be a useful treatment of severe asthma in certain patients under close observation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:177 |
|---|---|
| Enthalten in: |
Ugeskrift for laeger - 177(2015), 24 vom: 08. Juni, Seite 1159-63 |
| Sprache: |
Dänisch |
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| Weiterer Titel: |
Methotrexat kan anvendes som steroidbesparendebehandling af svær astma |
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| Beteiligte Personen: |
Knarborg, Malene [VerfasserIn] |
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| Themen: |
Adrenal Cortex Hormones |
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| Anmerkungen: |
Date Completed 29.05.2017 Date Revised 29.05.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Asthma is a chronic airway disease affecting many people worldwide. Less than 1% suffers from difficult-to-treat asthma and requires systemic corticosteroid treatment to achieve symptom control. The therapeutic options for these patients are limited and often we have to accept a lesser degree of symptom control. Methotrexate has been evaluated in 13 studies, where the mean corticosteroid dose reduction was 35%. Despite the adverse effects, we find that methotrexate may be a useful treatment of severe asthma in certain patients under close observation | ||
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