Incremental value of contrast enhanced computed tomography on diagnostic accuracy in evaluation of small pulmonary ground glass nodules
BACKGROUND: To evaluate the information gain by the application of both non-contrast and contrast enhanced computed tomography (CT) with extended mediastinal display window settings in the evaluation of pure ground glass nodules (pGGNs) and or mixed ground glass nodules (mGGNs) in the context of pre-invasive or early stage lung adenocarcinoma.
METHODS: One hundred and fifty patients with ground glass nodules (GGNs) and mGGNs, with contrast enhanced CT scans within 2 weeks of thoracic surgery were included in the study. Quantitative evaluation of all nodules was performed in a conventional mediastinal window (CMW) and an extended mediastinal window (EMW) both on non-contrast images and contrast-enhanced images.
RESULTS: Contrast-enhanced images with CMW demonstrated amplification of solid portion in 23 (43%), 41 (77%) with EMW out of 53 minimally invasive adenocarcinoma (MIA) nodules, and in 34 of 37 (91%) of invasive adenocarcinoma (IAC) nodules. Using the increase in size of solid portion of the nodule measured on the enhanced CT images with EMW, area under the receiver operating characteristic (ROC) curve of 0.872 and 0.899 was utilized for differentiating between the pre-invasive nodules and MIA and between MIA and IAC nodules, respectively. Statistically significant differences existed between the pre-invasive and the MIA groups, and MIA and the IAC groups in smaller nodules (P<0.01).
CONCLUSIONS: Comparative quantitative analysis of the pre and post contrast images can help differentiate between atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), MIAs, and IACs. Extension of the CT mediastinal window setting improves the evaluation of small GGNs, and can augment the diagnostic accuracy when evaluating small pGGNs and mGGNs.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2015 |
---|---|
Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
---|---|
Enthalten in: |
Journal of thoracic disease - 7(2015), 9 vom: 01. Sept., Seite 1606-15 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Li, Ming [VerfasserIn] |
---|
Links: |
---|
Themen: |
Enhancement |
---|
Anmerkungen: |
Date Completed 06.11.2015 Date Revised 11.03.2022 published: Print Citation Status PubMed-not-MEDLINE |
---|
doi: |
10.3978/j.issn.2072-1439.2015.09.37 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM254395554 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM254395554 | ||
003 | DE-627 | ||
005 | 20231226192328.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2015 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.3978/j.issn.2072-1439.2015.09.37 |2 doi | |
028 | 5 | 2 | |a pubmed24n0848.xml |
035 | |a (DE-627)NLM254395554 | ||
035 | |a (NLM)26543608 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Li, Ming |e verfasserin |4 aut | |
245 | 1 | 0 | |a Incremental value of contrast enhanced computed tomography on diagnostic accuracy in evaluation of small pulmonary ground glass nodules |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 06.11.2015 | ||
500 | |a Date Revised 11.03.2022 | ||
500 | |a published: Print | ||
500 | |a Citation Status PubMed-not-MEDLINE | ||
520 | |a BACKGROUND: To evaluate the information gain by the application of both non-contrast and contrast enhanced computed tomography (CT) with extended mediastinal display window settings in the evaluation of pure ground glass nodules (pGGNs) and or mixed ground glass nodules (mGGNs) in the context of pre-invasive or early stage lung adenocarcinoma | ||
520 | |a METHODS: One hundred and fifty patients with ground glass nodules (GGNs) and mGGNs, with contrast enhanced CT scans within 2 weeks of thoracic surgery were included in the study. Quantitative evaluation of all nodules was performed in a conventional mediastinal window (CMW) and an extended mediastinal window (EMW) both on non-contrast images and contrast-enhanced images | ||
520 | |a RESULTS: Contrast-enhanced images with CMW demonstrated amplification of solid portion in 23 (43%), 41 (77%) with EMW out of 53 minimally invasive adenocarcinoma (MIA) nodules, and in 34 of 37 (91%) of invasive adenocarcinoma (IAC) nodules. Using the increase in size of solid portion of the nodule measured on the enhanced CT images with EMW, area under the receiver operating characteristic (ROC) curve of 0.872 and 0.899 was utilized for differentiating between the pre-invasive nodules and MIA and between MIA and IAC nodules, respectively. Statistically significant differences existed between the pre-invasive and the MIA groups, and MIA and the IAC groups in smaller nodules (P<0.01) | ||
520 | |a CONCLUSIONS: Comparative quantitative analysis of the pre and post contrast images can help differentiate between atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), MIAs, and IACs. Extension of the CT mediastinal window setting improves the evaluation of small GGNs, and can augment the diagnostic accuracy when evaluating small pGGNs and mGGNs | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Lung adenocarcinoma | |
650 | 4 | |a X-ray computed | |
650 | 4 | |a enhancement | |
650 | 4 | |a ground glass nodules (GGNs) | |
650 | 4 | |a tomography | |
650 | 4 | |a window width/window level | |
700 | 1 | |a Gao, Feng |e verfasserin |4 aut | |
700 | 1 | |a Jagadeesan, Jayender |e verfasserin |4 aut | |
700 | 1 | |a Gill, Ritu R |e verfasserin |4 aut | |
700 | 1 | |a Hua, Yanqing |e verfasserin |4 aut | |
700 | 1 | |a Zheng, Xiangpeng |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of thoracic disease |d 2012 |g 7(2015), 9 vom: 01. Sept., Seite 1606-15 |w (DE-627)NLM219116938 |x 2072-1439 |7 nnns |
773 | 1 | 8 | |g volume:7 |g year:2015 |g number:9 |g day:01 |g month:09 |g pages:1606-15 |
856 | 4 | 0 | |u http://dx.doi.org/10.3978/j.issn.2072-1439.2015.09.37 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 7 |j 2015 |e 9 |b 01 |c 09 |h 1606-15 |