Advances in Computational Techniques to Study GPCR-Ligand Recognition
Copyright © 2015 Elsevier Ltd. All rights reserved..
G-protein-coupled receptors (GPCRs) are among the most intensely investigated drug targets. The recent revolutions in protein engineering and molecular modeling algorithms have overturned the research paradigm in the GPCR field. While the numerous ligand-bound X-ray structures determined have provided invaluable insights into GPCR structure and function, the development of algorithms exploiting graphics processing units (GPUs) has made the simulation of GPCRs in explicit lipid-water environments feasible within reasonable computation times. In this review we present a survey of the recent advances in structure-based drug design approaches with a particular emphasis on the elucidation of the ligand recognition process in class A GPCRs by means of membrane molecular dynamics (MD) simulations.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2015 |
---|---|
Erschienen: |
2015 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
---|---|
Enthalten in: |
Trends in pharmacological sciences - 36(2015), 12 vom: 14. Dez., Seite 878-890 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ciancetta, Antonella [VerfasserIn] |
---|
Links: |
---|
Themen: |
Journal Article |
---|
Anmerkungen: |
Date Completed 24.10.2016 Date Revised 26.02.2018 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.tips.2015.08.006 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM254343996 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM254343996 | ||
003 | DE-627 | ||
005 | 20231224172153.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2015 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.tips.2015.08.006 |2 doi | |
028 | 5 | 2 | |a pubmed24n0847.xml |
035 | |a (DE-627)NLM254343996 | ||
035 | |a (NLM)26538318 | ||
035 | |a (PII)S0165-6147(15)00167-4 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Ciancetta, Antonella |e verfasserin |4 aut | |
245 | 1 | 0 | |a Advances in Computational Techniques to Study GPCR-Ligand Recognition |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 24.10.2016 | ||
500 | |a Date Revised 26.02.2018 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
520 | |a G-protein-coupled receptors (GPCRs) are among the most intensely investigated drug targets. The recent revolutions in protein engineering and molecular modeling algorithms have overturned the research paradigm in the GPCR field. While the numerous ligand-bound X-ray structures determined have provided invaluable insights into GPCR structure and function, the development of algorithms exploiting graphics processing units (GPUs) has made the simulation of GPCRs in explicit lipid-water environments feasible within reasonable computation times. In this review we present a survey of the recent advances in structure-based drug design approaches with a particular emphasis on the elucidation of the ligand recognition process in class A GPCRs by means of membrane molecular dynamics (MD) simulations | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
650 | 7 | |a Ligands |2 NLM | |
650 | 7 | |a Receptors, G-Protein-Coupled |2 NLM | |
700 | 1 | |a Sabbadin, Davide |e verfasserin |4 aut | |
700 | 1 | |a Federico, Stephanie |e verfasserin |4 aut | |
700 | 1 | |a Spalluto, Giampiero |e verfasserin |4 aut | |
700 | 1 | |a Moro, Stefano |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Trends in pharmacological sciences |d 1989 |g 36(2015), 12 vom: 14. Dez., Seite 878-890 |w (DE-627)NLM012599670 |x 1873-3735 |7 nnns |
773 | 1 | 8 | |g volume:36 |g year:2015 |g number:12 |g day:14 |g month:12 |g pages:878-890 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.tips.2015.08.006 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 36 |j 2015 |e 12 |b 14 |c 12 |h 878-890 |