Rationale and Design of a Randomized Controlled Trial Evaluating Whole Muscle Exercise Training Effects in Outpatients with Pulmonary Arterial Hypertension (WHOLEi+12)
BACKGROUND AND AIMS: Physical exercise is an important component in the management of pulmonary artery hypertension (PAH). The aim of this randomized controlled trial (RCT) is to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure load exercises in PAH outpatients.
METHODS: The RCT will be conducted from September 2015 to September 2016 following the recommendations of the Consolidated Standards of Reported Trials (CONSORT), with a total sample size of n ≥ 48 (≥24 participants/group). We will determine the effects of the intervention on: (i) skeletal-muscle power and mass (primary end points); and (ii) NT-proBNP, cardiopulmonary exercise testing variables (VO2peak, ventilatory equivalent for CO2 at the anaerobic threshold (VE/VCO2 at the AT), end-tidal pressure of CO2 at the anaerobic threshold (PETCO2 at the AT), 6-min walking distance (6MWD), maximal inspiratory pressure (PImax), health-related quality of life (HRQoL), objectively-assessed spontaneous levels of physical activity, and safety (secondary end points).
CONCLUSIONS AND PERSPECTIVES: This trial will provide insight into biological mechanisms of the disease and indicate the potential benefits of exercise in PAH outpatients, particularly on muscle power.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Cardiovascular drugs and therapy - 29(2015), 6 vom: 31. Dez., Seite 543-550 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sanchis-Gomar, Fabian [VerfasserIn] |
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| Links: |
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| Themen: |
Cardio-pulmonary exercise testing |
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| Anmerkungen: |
Date Revised 18.03.2022 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1007/s10557-015-6623-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM254207227 |
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| 520 | |a BACKGROUND AND AIMS: Physical exercise is an important component in the management of pulmonary artery hypertension (PAH). The aim of this randomized controlled trial (RCT) is to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure load exercises in PAH outpatients | ||
| 520 | |a METHODS: The RCT will be conducted from September 2015 to September 2016 following the recommendations of the Consolidated Standards of Reported Trials (CONSORT), with a total sample size of n ≥ 48 (≥24 participants/group). We will determine the effects of the intervention on: (i) skeletal-muscle power and mass (primary end points); and (ii) NT-proBNP, cardiopulmonary exercise testing variables (VO2peak, ventilatory equivalent for CO2 at the anaerobic threshold (VE/VCO2 at the AT), end-tidal pressure of CO2 at the anaerobic threshold (PETCO2 at the AT), 6-min walking distance (6MWD), maximal inspiratory pressure (PImax), health-related quality of life (HRQoL), objectively-assessed spontaneous levels of physical activity, and safety (secondary end points) | ||
| 520 | |a CONCLUSIONS AND PERSPECTIVES: This trial will provide insight into biological mechanisms of the disease and indicate the potential benefits of exercise in PAH outpatients, particularly on muscle power | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardio-pulmonary exercise testing | |
| 650 | 4 | |a NT-proBNP | |
| 650 | 4 | |a Pulmonary disease | |
| 650 | 4 | |a Resistance exercise | |
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| 700 | 1 | |a González-Saiz, Laura |e verfasserin |4 aut | |
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| 700 | 1 | |a Fiuza-Luces, Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Quezada-Loaiza, Carlos A |e verfasserin |4 aut | |
| 700 | 1 | |a Flox-Camacho, Angela |e verfasserin |4 aut | |
| 700 | 1 | |a Santalla, Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Munguía-Izquierdo, Diego |e verfasserin |4 aut | |
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| 700 | 1 | |a Pareja-Galeano, Helios |e verfasserin |4 aut | |
| 700 | 1 | |a Ara, Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Escribano-Subías, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Lucia, Alejandro |e verfasserin |4 aut | |
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