Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation : an observational study from the outpatient clinic
The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an outpatients clinic in Nagoya University Hospital included 413 patients ≥70 years old (99 obese: BMI ≥25 kg/m(2); 256 normal weight: BMI 18.5-24.9 kg/m(2); and 58 underweight patients: BMI <18.5 kg/m(2)). The mean age was 77.5 ± 5.6 years. During a mean follow-up of 19.0 months, all-cause death occurred in 23 patients (obese 1 %, normal weight 5.1 %, and underweight 16 %). The major adverse events including all-cause death, stroke or transient ischemic attack, heart failure requiring admission, and acute coronary syndrome were observed in 53 patients (obese 5.1 %, normal weight 13 %, and underweight 26 %). After adjusting for confounding factors, the underweight group had a significantly greater risk for all-cause death [hazard ratio (HR) 2.91, 95 % confidence interval (CI) 1.12-7.60, p = 0.029], and major adverse events (HR 2.45, 95 % CI 1.25-4.78, p = 0.009) than the normal weight group. In contrast, the obese group had a better prognosis in major adverse events compared with the normal weight group (HR 0.34, 95 % CI 0.13-0.89, p = 0.029). In conclusion, lower BMI was independently associated with poor outcomes among older AF patients. The association between obesity and better prognosis in elderly AF patients was also found.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
|---|---|
| Enthalten in: |
Heart and vessels - 31(2016), 9 vom: 24. Sept., Seite 1553-61 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yanagisawa, Satoshi [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Atrial fibrillation |
|---|
| Anmerkungen: |
Date Completed 24.04.2017 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00380-015-0765-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM253992915 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM253992915 | ||
| 003 | DE-627 | ||
| 005 | 20231224171420.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00380-015-0765-y |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0846.xml |
| 035 | |a (DE-627)NLM253992915 | ||
| 035 | |a (NLM)26498940 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yanagisawa, Satoshi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Body mass index is associated with prognosis in Japanese elderly patients with atrial fibrillation |b an observational study from the outpatient clinic |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 24.04.2017 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The relationship between body mass index (BMI) and the prognosis of elderly patients with atrial fibrillation (AF) is unknown. We aimed to examine the association of body weight with the clinical outcomes among Japanese elderly patients with a history of documented AF. This observational study of AF patients from an outpatients clinic in Nagoya University Hospital included 413 patients ≥70 years old (99 obese: BMI ≥25 kg/m(2); 256 normal weight: BMI 18.5-24.9 kg/m(2); and 58 underweight patients: BMI <18.5 kg/m(2)). The mean age was 77.5 ± 5.6 years. During a mean follow-up of 19.0 months, all-cause death occurred in 23 patients (obese 1 %, normal weight 5.1 %, and underweight 16 %). The major adverse events including all-cause death, stroke or transient ischemic attack, heart failure requiring admission, and acute coronary syndrome were observed in 53 patients (obese 5.1 %, normal weight 13 %, and underweight 26 %). After adjusting for confounding factors, the underweight group had a significantly greater risk for all-cause death [hazard ratio (HR) 2.91, 95 % confidence interval (CI) 1.12-7.60, p = 0.029], and major adverse events (HR 2.45, 95 % CI 1.25-4.78, p = 0.009) than the normal weight group. In contrast, the obese group had a better prognosis in major adverse events compared with the normal weight group (HR 0.34, 95 % CI 0.13-0.89, p = 0.029). In conclusion, lower BMI was independently associated with poor outcomes among older AF patients. The association between obesity and better prognosis in elderly AF patients was also found | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Atrial fibrillation | |
| 650 | 4 | |a Body mass index | |
| 650 | 4 | |a Elderly | |
| 650 | 4 | |a Obesity paradox | |
| 650 | 4 | |a Prognosis | |
| 700 | 1 | |a Inden, Yasuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Kato, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Miyoshi-Fujii, Aya |e verfasserin |4 aut | |
| 700 | 1 | |a Mizutani, Yoshiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Tadahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Kamikubo, Yosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Kanzaki, Yasunori |e verfasserin |4 aut | |
| 700 | 1 | |a Hirai, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Murohara, Toyoaki |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Heart and vessels |d 1993 |g 31(2016), 9 vom: 24. Sept., Seite 1553-61 |w (DE-627)NLM012974587 |x 1615-2573 |7 nnns |
| 773 | 1 | 8 | |g volume:31 |g year:2016 |g number:9 |g day:24 |g month:09 |g pages:1553-61 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00380-015-0765-y |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 31 |j 2016 |e 9 |b 24 |c 09 |h 1553-61 | ||