Ebola Virus Outbreak Investigation, Sierra Leone, September 28-November 11, 2014
During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. The China Mobile Laboratory Testing Team was dispatched to support response efforts; during September 28-November 11, 2014, they conducted PCR testing on samples from 1,635 suspected EVD patients. Of those patients, 50.4% were positive, of whom 84.6% lived within a 3-km zone along main roads connecting rural towns and densely populated cities. The median time from symptom onset to testing was 5 days. At testing, 75.7% of the confirmed patients had fever, and 94.1% reported at least 1 gastrointestinal symptom; all symptoms, except rash and hemorrhage, were more frequent in confirmed than nonconfirmed patients. Virus loads were significantly higher in EVD patients with fever, diarrhea, fatigue, or headache. The case-fatality rate was lower among patients 15-44 years of age and with virus loads of <100,000 RNA copies/mL. These findings are key for optimizing EVD control and treatment measures.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Emerging infectious diseases - 21(2015), 11 vom: 06. Nov., Seite 1921-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Hui-Jun [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 17.05.2016 Date Revised 30.03.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid2111.150582 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM253860407 |
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| 520 | |a During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. The China Mobile Laboratory Testing Team was dispatched to support response efforts; during September 28-November 11, 2014, they conducted PCR testing on samples from 1,635 suspected EVD patients. Of those patients, 50.4% were positive, of whom 84.6% lived within a 3-km zone along main roads connecting rural towns and densely populated cities. The median time from symptom onset to testing was 5 days. At testing, 75.7% of the confirmed patients had fever, and 94.1% reported at least 1 gastrointestinal symptom; all symptoms, except rash and hemorrhage, were more frequent in confirmed than nonconfirmed patients. Virus loads were significantly higher in EVD patients with fever, diarrhea, fatigue, or headache. The case-fatality rate was lower among patients 15-44 years of age and with virus loads of <100,000 RNA copies/mL. These findings are key for optimizing EVD control and treatment measures | ||
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| 700 | 1 | |a Sun, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Yu-Xi |e verfasserin |4 aut | |
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| 700 | 1 | |a Su, Hao-Xiang |e verfasserin |4 aut | |
| 700 | 1 | |a Dafae, Foday |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Cheng-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Nie, Wei-Min |e verfasserin |4 aut | |
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| 700 | 1 | |a Gao, George F |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Jia-Fu |e verfasserin |4 aut | |
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