Poly(ADP-ribosyl)ation as a new posttranslational modification of YB-1
Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved..
Multifunctional Y-box binding protein 1 (YB-1) is actively studied as one of the components of cellular response to genotoxic stress. However, the precise role of YB-1 in the process of DNA repair is still obscure. In the present work we report for the first time new posttranslational modification of YB-1 - poly(ADP-ribosyl)ation, catalyzed by one of the main regulatory enzymes of DNA repair - poly(ADP-ribose)polymerase 1 (PARP1) in the presence of model DNA substrate carrying multiple DNA lesions. Therefore, poly(ADP-ribosyl)ation of YB-1 catalyzed with PARP1, can be stimulated by damaged DNA. The observed property of YB-1 underlines its ability to participate in the DNA repair by its involvement in the regulatory cascades of DNA repair.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:119 |
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| Enthalten in: |
Biochimie - 119(2015) vom: 10. Dez., Seite 36-44 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alemasova, Elizaveta E [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.12.2016 Date Revised 30.12.2016 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.biochi.2015.10.008 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM253555361 |
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| 500 | |a Date Completed 13.12.2016 | ||
| 500 | |a Date Revised 30.12.2016 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. | ||
| 520 | |a Multifunctional Y-box binding protein 1 (YB-1) is actively studied as one of the components of cellular response to genotoxic stress. However, the precise role of YB-1 in the process of DNA repair is still obscure. In the present work we report for the first time new posttranslational modification of YB-1 - poly(ADP-ribosyl)ation, catalyzed by one of the main regulatory enzymes of DNA repair - poly(ADP-ribose)polymerase 1 (PARP1) in the presence of model DNA substrate carrying multiple DNA lesions. Therefore, poly(ADP-ribosyl)ation of YB-1 catalyzed with PARP1, can be stimulated by damaged DNA. The observed property of YB-1 underlines its ability to participate in the DNA repair by its involvement in the regulatory cascades of DNA repair | ||
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| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Pestryakov, Pavel E |e verfasserin |4 aut | |
| 700 | 1 | |a Sukhanova, Maria V |e verfasserin |4 aut | |
| 700 | 1 | |a Kretov, Dmitry A |e verfasserin |4 aut | |
| 700 | 1 | |a Moor, Nina A |e verfasserin |4 aut | |
| 700 | 1 | |a Curmi, Patrick A |e verfasserin |4 aut | |
| 700 | 1 | |a Ovchinnikov, Lev P |e verfasserin |4 aut | |
| 700 | 1 | |a Lavrik, Olga I |e verfasserin |4 aut | |
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