Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression : A Retrospective Cohort Study
OBJECTIVE: Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia. The present study was conducted to assess whether statins can reduce the risk of dementia in these patients.
METHODS: We used the data from National Health Insurance of Taiwan during 1996-2009. Standardized Incidence Ratios (SIRs) were calculated for LOD and subsequent dementia. The criteria for LOD diagnoses included age ≥65 years, diagnosis of depression after 65 years of age, at least three service claims, and treatment with antidepressants. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to select matching patients for validation studies. Kaplan-Meier curve estimate was used to measure the group of patients with dementia living after diagnosis of LOD.
RESULTS: Totally 45,973 patients aged ≥65 years were enrolled. The prevalence of LOD was 12.9% (5,952/45,973). Patients with LOD showed to have a higher incidence of subsequent dementia compared with those without LOD (Odds Ratio: 2.785; 95% CI 2.619-2.958). Among patients with LOD, lipid lowering agent (LLA) users (for at least 3 months) had lower incidence of subsequent dementia than non-users (Hazard Ratio = 0.781, 95% CI 0.685-0.891). Nevertheless, only statins users showed to have reduced risk of dementia (Hazard Ratio = 0.674, 95% CI 0.547-0.832) while other LLAs did not, which was further validated by Kaplan-Meier estimates after we used the propensity scores with the one-to-one nearest-neighbor matching model to control the confounding factors.
CONCLUSIONS: Statins may reduce the risk of subsequent dementia in patients with LOD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
PloS one - 10(2015), 9 vom: 17., Seite e0137914 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yang, Ya-Hsu [VerfasserIn] |
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| Links: |
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| Themen: |
Hydroxymethylglutaryl-CoA Reductase Inhibitors |
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| Anmerkungen: |
Date Completed 26.05.2016 Date Revised 13.11.2018 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0137914 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM252880110 |
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| 100 | 1 | |a Yang, Ya-Hsu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Statins Reduces the Risk of Dementia in Patients with Late-Onset Depression |b A Retrospective Cohort Study |
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| 500 | |a Date Revised 13.11.2018 | ||
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Patients with late-onset depression (LOD) have been reported to run a higher risk of subsequent dementia. The present study was conducted to assess whether statins can reduce the risk of dementia in these patients | ||
| 520 | |a METHODS: We used the data from National Health Insurance of Taiwan during 1996-2009. Standardized Incidence Ratios (SIRs) were calculated for LOD and subsequent dementia. The criteria for LOD diagnoses included age ≥65 years, diagnosis of depression after 65 years of age, at least three service claims, and treatment with antidepressants. The time-dependent Cox proportional hazards model was applied for multivariate analyses. Propensity scores with the one-to-one nearest-neighbor matching model were used to select matching patients for validation studies. Kaplan-Meier curve estimate was used to measure the group of patients with dementia living after diagnosis of LOD | ||
| 520 | |a RESULTS: Totally 45,973 patients aged ≥65 years were enrolled. The prevalence of LOD was 12.9% (5,952/45,973). Patients with LOD showed to have a higher incidence of subsequent dementia compared with those without LOD (Odds Ratio: 2.785; 95% CI 2.619-2.958). Among patients with LOD, lipid lowering agent (LLA) users (for at least 3 months) had lower incidence of subsequent dementia than non-users (Hazard Ratio = 0.781, 95% CI 0.685-0.891). Nevertheless, only statins users showed to have reduced risk of dementia (Hazard Ratio = 0.674, 95% CI 0.547-0.832) while other LLAs did not, which was further validated by Kaplan-Meier estimates after we used the propensity scores with the one-to-one nearest-neighbor matching model to control the confounding factors | ||
| 520 | |a CONCLUSIONS: Statins may reduce the risk of subsequent dementia in patients with LOD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Hydroxymethylglutaryl-CoA Reductase Inhibitors |2 NLM | |
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| 700 | 1 | |a Lai, Yen-Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Szu-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Chih-Ching |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Albert C |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Hsiang-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Hsieh, Yi-Hsuan |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Chiao-Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Hsu, Fu-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Chih-Kuang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Wen-Sheng |e verfasserin |4 aut | |
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