Modern Intermittent Haemodialysis (IHD) is an Effective Method of Removing Salicylate in Chronic Topical Salicylate Toxicity
INTRODUCTION: There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning.
CASE REPORT: A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N < 0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed.
DISCUSSION: Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Journal of medical toxicology : official journal of the American College of Medical Toxicology - 12(2016), 1 vom: 03. März, Seite 130-3 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wong, Anselm [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antirheumatic Agents |
|---|
| Anmerkungen: |
Date Completed 21.12.2016 Date Revised 13.11.2018 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1007/s13181-015-0502-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM252407490 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM252407490 | ||
| 003 | DE-627 | ||
| 005 | 20231224164043.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s13181-015-0502-z |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0841.xml |
| 035 | |a (DE-627)NLM252407490 | ||
| 035 | |a (NLM)26334327 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wong, Anselm |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Modern Intermittent Haemodialysis (IHD) is an Effective Method of Removing Salicylate in Chronic Topical Salicylate Toxicity |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.12.2016 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning | ||
| 520 | |a CASE REPORT: A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N < 0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed | ||
| 520 | |a DISCUSSION: Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Hemodialysis | |
| 650 | 4 | |a Poisoning | |
| 650 | 4 | |a Salicylate | |
| 650 | 4 | |a Topical | |
| 650 | 7 | |a Antirheumatic Agents |2 NLM | |
| 650 | 7 | |a Salicylates |2 NLM | |
| 650 | 7 | |a methyl salicylate |2 NLM | |
| 650 | 7 | |a LAV5U5022Y |2 NLM | |
| 700 | 1 | |a Mac, Kathy |e verfasserin |4 aut | |
| 700 | 1 | |a Aneman, Anders |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Betty S |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of medical toxicology : official journal of the American College of Medical Toxicology |d 2005 |g 12(2016), 1 vom: 03. März, Seite 130-3 |w (DE-627)NLM175675902 |x 1937-6995 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2016 |g number:1 |g day:03 |g month:03 |g pages:130-3 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s13181-015-0502-z |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2016 |e 1 |b 03 |c 03 |h 130-3 | ||