Corneal Cross-linking to Halt the Progression of Keratoconus and Corneal Ectasia : Seven-Year Follow-up
Copyright © 2015 Elsevier Inc. All rights reserved..
PURPOSE: To determine long-term efficacy and safety of riboflavin/ultraviolet A corneal cross-linking (CXL).
DESIGN: Prospective cohort study.
METHODS: Thirty-six patients (36 eyes) who underwent epithelium-off CXL at a University Hospital (Guy's and St Thomas' National Health Service Foundation Trust) 6-8 years previously were examined. The main outcome measures were refractive error, visual acuity, corneal topographic keratometry, ultrasonic pachymetry, and topography-derived corneal wavefront.
RESULTS: At 7 years compared to preoperative values, mean spherical equivalent refractive error (SEQ) increased by +0.78 diopter (D) (P < .005) and mean simulated topographic keratometry (SimK) and mean maximum keratometry (Kmax) reduced by -0.74 D (P < .0001) and -0.91 D (P < .0001), respectively. Uncorrected distance acuity (UCDA) (P < .0005) and corrected distance acuity (CDVA) (P < .0001) had improved and root mean square (RMS) (P < .0005), coma (P < .0005), and secondary astigmatism (P < .005) lessened. At 7 years compared to 1 year, CDVA improved (P < .05); mean SimK (P < .0005) and mean Kmax (P < .005) reduced by -0.45 D and -0.56 D, respectively; and RMS (P < .0005) and coma (P < .0005) decreased. At 7 years compared to 5 years, CDVA improved (P < .05) and trefoil reduced (P < .05). No treated eyes progressed. In 29 initially untreated fellow eyes mean SimK increased by +0.54 D (P < .02), mean Kmax by +0.87 D (P < .05), and refractive astigmatism increased (P < .0005).
CONCLUSIONS: Following corneal cross-linking, improvements in topographic and wavefront parameters evident at 1 year were seen to continue to improve at 5 years and were maintained at 7 years. No treated eyes progressed over the 7-year follow-up period.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
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| Enthalten in: |
American journal of ophthalmology - 160(2015), 6 vom: 26. Dez., Seite 1154-63 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
O'Brart, David P S [VerfasserIn] |
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| Links: |
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| Themen: |
Cross-Linking Reagents |
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| Anmerkungen: |
Date Completed 23.02.2016 Date Revised 08.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ajo.2015.08.023 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM252162366 |
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| 100 | 1 | |a O'Brart, David P S |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Corneal Cross-linking to Halt the Progression of Keratoconus and Corneal Ectasia |b Seven-Year Follow-up |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.02.2016 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 520 | |a PURPOSE: To determine long-term efficacy and safety of riboflavin/ultraviolet A corneal cross-linking (CXL) | ||
| 520 | |a DESIGN: Prospective cohort study | ||
| 520 | |a METHODS: Thirty-six patients (36 eyes) who underwent epithelium-off CXL at a University Hospital (Guy's and St Thomas' National Health Service Foundation Trust) 6-8 years previously were examined. The main outcome measures were refractive error, visual acuity, corneal topographic keratometry, ultrasonic pachymetry, and topography-derived corneal wavefront | ||
| 520 | |a RESULTS: At 7 years compared to preoperative values, mean spherical equivalent refractive error (SEQ) increased by +0.78 diopter (D) (P < .005) and mean simulated topographic keratometry (SimK) and mean maximum keratometry (Kmax) reduced by -0.74 D (P < .0001) and -0.91 D (P < .0001), respectively. Uncorrected distance acuity (UCDA) (P < .0005) and corrected distance acuity (CDVA) (P < .0001) had improved and root mean square (RMS) (P < .0005), coma (P < .0005), and secondary astigmatism (P < .005) lessened. At 7 years compared to 1 year, CDVA improved (P < .05); mean SimK (P < .0005) and mean Kmax (P < .005) reduced by -0.45 D and -0.56 D, respectively; and RMS (P < .0005) and coma (P < .0005) decreased. At 7 years compared to 5 years, CDVA improved (P < .05) and trefoil reduced (P < .05). No treated eyes progressed. In 29 initially untreated fellow eyes mean SimK increased by +0.54 D (P < .02), mean Kmax by +0.87 D (P < .05), and refractive astigmatism increased (P < .0005) | ||
| 520 | |a CONCLUSIONS: Following corneal cross-linking, improvements in topographic and wavefront parameters evident at 1 year were seen to continue to improve at 5 years and were maintained at 7 years. No treated eyes progressed over the 7-year follow-up period | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Cross-Linking Reagents |2 NLM | |
| 650 | 7 | |a Photosensitizing Agents |2 NLM | |
| 650 | 7 | |a Riboflavin |2 NLM | |
| 650 | 7 | |a TLM2976OFR |2 NLM | |
| 700 | 1 | |a Patel, Parul |e verfasserin |4 aut | |
| 700 | 1 | |a Lascaratos, Gerassimos |e verfasserin |4 aut | |
| 700 | 1 | |a Wagh, Vijay K |e verfasserin |4 aut | |
| 700 | 1 | |a Tam, Connan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a O'Brart, Naomi A |e verfasserin |4 aut | |
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