Update on leukoreduction therapies as alternatives for the treatment of severe pertussis
Pertussis is a contagious disease that in patients under 1 year of age may evolve to a highly lethal course characterized by hypoxemia and refractory pulmonary hypertension, being this responsible for cardiovascular collapse. Pulmonary hypertension occurs by direct action of bacteria and its toxins, responsible for the vascular tone alteration associated with hyperviscosity syndrome and arteriolar thrombosis due to hyperleukocytosis. Since 2004, leucodepletion has been proposed as a treatment option; there are currently 18 publications on leucodepletion in patients with severe Pertussis, with a total of 288 patients, 68 cytoreduction procedures and a mortality rate of 28% in those exposed to the mentioned treatment. Published studies have design limitations, so the evidence for using leukoreduction in patients with severe pertussis remains low.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:113 |
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| Enthalten in: |
Archivos argentinos de pediatria - 113(2015), 5 vom: 15. Okt., Seite 456-64 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Actualización en terapias de leucorreducción como alternativas para el tratamiento de coqueluche grave |
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| Beteiligte Personen: |
Taffarel, Pedro [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 07.07.2017 Date Revised 18.07.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.5546/aap.2015.456 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM252031628 |
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| 520 | |a Pertussis is a contagious disease that in patients under 1 year of age may evolve to a highly lethal course characterized by hypoxemia and refractory pulmonary hypertension, being this responsible for cardiovascular collapse. Pulmonary hypertension occurs by direct action of bacteria and its toxins, responsible for the vascular tone alteration associated with hyperviscosity syndrome and arteriolar thrombosis due to hyperleukocytosis. Since 2004, leucodepletion has been proposed as a treatment option; there are currently 18 publications on leucodepletion in patients with severe Pertussis, with a total of 288 patients, 68 cytoreduction procedures and a mortality rate of 28% in those exposed to the mentioned treatment. Published studies have design limitations, so the evidence for using leukoreduction in patients with severe pertussis remains low | ||
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