Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders
Neurodegenerative diseases represent a challenge for biomedical research due to their high prevalence and lack of mechanism-based treatments. Because of the complex pathology of neurodegenerative disorders, multifunctional drugs have been increasingly recognized as potential treatments. We identified homobivalent γ-carbolinium salts as potent inihitors of both cholinesterases, N-methyl-D-aspartate receptors, and monoamine oxidases. Homobivalent γ-carbolines displayed similar structure-activity relationships on all tested targets and may present promising designed multiple ligands for the treatment of neurodegenerative disorders.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Journal of medicinal chemistry - 58(2015), 16 vom: 27. Aug., Seite 6710-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Otto, Robert [VerfasserIn] |
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| Links: |
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| Themen: |
Carbolines |
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| Anmerkungen: |
Date Completed 16.11.2015 Date Revised 28.08.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acs.jmedchem.5b00958 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM251884511 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Neurodegenerative diseases represent a challenge for biomedical research due to their high prevalence and lack of mechanism-based treatments. Because of the complex pathology of neurodegenerative disorders, multifunctional drugs have been increasingly recognized as potential treatments. We identified homobivalent γ-carbolinium salts as potent inihitors of both cholinesterases, N-methyl-D-aspartate receptors, and monoamine oxidases. Homobivalent γ-carbolines displayed similar structure-activity relationships on all tested targets and may present promising designed multiple ligands for the treatment of neurodegenerative disorders | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Carbolines |2 NLM | |
| 650 | 7 | |a Cholinesterase Inhibitors |2 NLM | |
| 650 | 7 | |a Excitatory Amino Acid Antagonists |2 NLM | |
| 650 | 7 | |a Indicators and Reagents |2 NLM | |
| 650 | 7 | |a Ligands |2 NLM | |
| 650 | 7 | |a Monoamine Oxidase Inhibitors |2 NLM | |
| 650 | 7 | |a Receptors, N-Methyl-D-Aspartate |2 NLM | |
| 700 | 1 | |a Penzis, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Gaube, Friedemann |e verfasserin |4 aut | |
| 700 | 1 | |a Adolph, Oliver |e verfasserin |4 aut | |
| 700 | 1 | |a Föhr, Karl J |e verfasserin |4 aut | |
| 700 | 1 | |a Warncke, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Robaa, Dina |e verfasserin |4 aut | |
| 700 | 1 | |a Appenroth, Dorothea |e verfasserin |4 aut | |
| 700 | 1 | |a Fleck, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Enzensperger, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Lehmann, Jochen |e verfasserin |4 aut | |
| 700 | 1 | |a Winckler, Thomas |e verfasserin |4 aut | |
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