A Kinase Divided
Copyright © 2015 Elsevier Inc. All rights reserved..
In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance.
| Errataetall: |
CommentOn: Cancer Cell. 2015 Aug 10;28(2):170-82. - PMID 26267534 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
|---|---|
| Enthalten in: |
Cancer cell - 28(2015), 2 vom: 10. Aug., Seite 145-7 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Karra, Aroon S [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Comment |
|---|
| Anmerkungen: |
Date Completed 25.11.2015 Date Revised 02.12.2018 published: Print CommentOn: Cancer Cell. 2015 Aug 10;28(2):170-82. - PMID 26267534 Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ccell.2015.07.008 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM251777634 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM251777634 | ||
| 003 | DE-627 | ||
| 005 | 20231224162732.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ccell.2015.07.008 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0839.xml |
| 035 | |a (DE-627)NLM251777634 | ||
| 035 | |a (NLM)26267529 | ||
| 035 | |a (PII)S1535-6108(15)00260-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Karra, Aroon S |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A Kinase Divided |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.11.2015 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentOn: Cancer Cell. 2015 Aug 10;28(2):170-82. - PMID 26267534 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 520 | |a In this issue of Cancer Cell, Herrero and colleagues identify an anti-tumorigenic small molecule that blocks ERK dimerization, but neither its catalytic activity nor its phosphorylation by MEK. These findings demonstrate that targeting protein dimerization could be a therapeutic avenue for inhibiting kinase signaling pathways associated with lower drug resistance | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Comment | |
| 650 | 7 | |a Small Molecule Libraries |2 NLM | |
| 650 | 7 | |a Mitogen-Activated Protein Kinase 1 |2 NLM | |
| 650 | 7 | |a EC 2.7.11.24 |2 NLM | |
| 650 | 7 | |a ras Proteins |2 NLM | |
| 650 | 7 | |a EC 3.6.5.2 |2 NLM | |
| 700 | 1 | |a Taylor, Clinton A |c 4th |e verfasserin |4 aut | |
| 700 | 1 | |a Thorne, Curtis A |e verfasserin |4 aut | |
| 700 | 1 | |a Cobb, Melanie H |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer cell |d 2002 |g 28(2015), 2 vom: 10. Aug., Seite 145-7 |w (DE-627)NLM119589826 |x 1878-3686 |7 nnns |
| 773 | 1 | 8 | |g volume:28 |g year:2015 |g number:2 |g day:10 |g month:08 |g pages:145-7 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ccell.2015.07.008 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 28 |j 2015 |e 2 |b 10 |c 08 |h 145-7 | ||