Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release
Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC-phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug-phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
ACS applied materials & interfaces - 7(2015), 32 vom: 19. Aug., Seite 17573-81 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Yang [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.07.2016 Date Revised 30.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/acsami.5b05038 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM251456579 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Integrating advantages of mitomycin C (MMC)-phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC-phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug-phospholipid complex-based targeted drug delivery system for sustained/controlled drug release | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a anticancer-phospholipid complex | |
| 650 | 4 | |a nanoparticles | |
| 650 | 4 | |a self-assembly | |
| 650 | 4 | |a sustained/controlled drug release | |
| 650 | 4 | |a targeted drug delivery | |
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| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Phospholipids |2 NLM | |
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| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
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| 700 | 1 | |a Lin, Jinyan |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xiangrui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yanxiu |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shichao |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Shefang |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Liya |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Lizong |e verfasserin |4 aut | |
| 700 | 1 | |a Hou, Zhenqing |e verfasserin |4 aut | |
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