Clinical characteristics of adult patients with herpetic meningoencephalitis : a nested case control study
INTRODUCTION: Herpes simplex virus (HSV) is the most common etiology of sporadic encephalitis and presents with an estimated mortality of 50-70%.
OBJECTIVE: To describe baseline characteristics of patients with herpetic encephalitis admitted to a tertiary teaching hospital and their difference with patients with non herpetic encephalitis.
MATERIALS AND METHODS: Nested case control study using a retrospective cohort of patients with suspected encephalitis admitted to the Hospital Italiano de Buenos Aires (2006-2013). Adult patients included had a lumbar puncture with a positive or negative polimerase reaction for HSV. A case of herpetic encephalitis was defined as a positive polimerase reaction in spinal fluid. For each case, 5 controls were randomly selected.
RESULTS: There were no baseline differences present between cases and controls. The only covariate associated with herpetic encephalitis was an abnormal brain magnetic resonance imaging (MRI) (OR: 5.37, IC 95% 1.42-20.38, p < 0.01). The most frecuent alterations in the MRI were extratemporal lesions or temporal ones with or without haemorrhage.
DISCUSSION: There are no apparent baseline clinical differences between patients with or without herpetic encephalitis. A positive finding in a brain MRI should be taken into account during clinical workup.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia - 32(2015), 3 vom: 09. Juni, Seite 266-71 |
| Sprache: |
Spanisch |
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| Weiterer Titel: |
Variables clínicas asociadas al diagnóstico de meningo-encefalitis herpética en pacientes adultos: un estudio anidado de casos y controles |
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| Beteiligte Personen: |
Magaz, María de Las Mercedes [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.03.2016 Date Revised 03.08.2015 published: Print Citation Status MEDLINE |
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| doi: |
10.4067/S0716-10182015000400002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM251418251 |
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| 100 | 1 | |a Magaz, María de Las Mercedes |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical characteristics of adult patients with herpetic meningoencephalitis |b a nested case control study |
| 246 | 3 | 3 | |a Variables clínicas asociadas al diagnóstico de meningo-encefalitis herpética en pacientes adultos: un estudio anidado de casos y controles |
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| 500 | |a Date Completed 03.03.2016 | ||
| 500 | |a Date Revised 03.08.2015 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Herpes simplex virus (HSV) is the most common etiology of sporadic encephalitis and presents with an estimated mortality of 50-70% | ||
| 520 | |a OBJECTIVE: To describe baseline characteristics of patients with herpetic encephalitis admitted to a tertiary teaching hospital and their difference with patients with non herpetic encephalitis | ||
| 520 | |a MATERIALS AND METHODS: Nested case control study using a retrospective cohort of patients with suspected encephalitis admitted to the Hospital Italiano de Buenos Aires (2006-2013). Adult patients included had a lumbar puncture with a positive or negative polimerase reaction for HSV. A case of herpetic encephalitis was defined as a positive polimerase reaction in spinal fluid. For each case, 5 controls were randomly selected | ||
| 520 | |a RESULTS: There were no baseline differences present between cases and controls. The only covariate associated with herpetic encephalitis was an abnormal brain magnetic resonance imaging (MRI) (OR: 5.37, IC 95% 1.42-20.38, p < 0.01). The most frecuent alterations in the MRI were extratemporal lesions or temporal ones with or without haemorrhage | ||
| 520 | |a DISCUSSION: There are no apparent baseline clinical differences between patients with or without herpetic encephalitis. A positive finding in a brain MRI should be taken into account during clinical workup | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wainsztein, Vanna |e verfasserin |4 aut | |
| 700 | 1 | |a Maritano, Joaquín |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez, María Nelly |e verfasserin |4 aut | |
| 700 | 1 | |a Binder, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreyro, Bruno L |e verfasserin |4 aut | |
| 700 | 1 | |a Angriman, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Waisman, Gabriel |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:32 |g year:2015 |g number:3 |g day:09 |g month:06 |g pages:266-71 |
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