Desflurane and sevoflurane use during low- and minimal-flow anesthesia at fixed vaporizer settings
BACKGROUND: The pharmacokinetics for sevoflurane and desflurane makes them suitable for low-flow anesthesia. The aim of the present study was to assess the use of desflurane and sevoflurane at constant vaporizer settings and fixed low fresh gas flows.
METHODS: One hundred ASA 1-2 patients undergoing elective laparoscopic surgery were randomized into 4 groups (25 patients each): a fixed fresh gas flow 1.0 or 0.5 L/min with desflurane (D1.0 and D0.5) or sevoflurane (S1.0 and S0.5) throughout anesthesia. A fixed vaporizer setting, sevoflurane 6% and desflurane 18% was used during wash-in. Time to reach 1 and 1.5 minimum alveolar concentration (MAC), emergence and gas consumption from start to end of surgery was studied.
RESULTS: Time to reach 1 MAC age adjusted desflurane or sevoflurane was D0.5 8.5±1.7, D1.0 3.7±0.7, S0.5 15.2±2.4 and S1.0 6.2±1.3 minutes, respectively (P<0.001), and times to increase from 1 to 1.5 MAC differed also significantly. Desflurane anesthesia was associated to significantly shorter time to extubation 6.7±2.3 vs. 10±2.3 minutes for sevoflurane (P<0.001). The amount of agent consumed g/min. was significantly reduced for both 0.5 L/min groups: 30% less for desflurane and 19% for sevoflurane.
CONCLUSIONS: We found an almost twice as rapid wash-in with desflurane and expectedly faster emergence. Gas consumption was lower at 0.5 L/min than it was at 1 L/min for both gases studied however most pronounced for desflurane. Desflurane has clear advantages for minimal fresh gas flow anesthesia.
| Errataetall: |
CommentIn: Minerva Anestesiol. 2016 Feb;82(2):149-50. - PMID 26449777 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:82 |
|---|---|
| Enthalten in: |
Minerva anestesiologica - 82(2016), 2 vom: 12. Feb., Seite 180-5 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Horwitz, Maria [VerfasserIn] |
|---|
| Themen: |
38LVP0K73A |
|---|
| Anmerkungen: |
Date Completed 23.02.2017 Date Revised 02.12.2018 published: Print-Electronic CommentIn: Minerva Anestesiol. 2016 Feb;82(2):149-50. - PMID 26449777 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM251115445 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM251115445 | ||
| 003 | DE-627 | ||
| 005 | 20231224161313.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2016 xx |||||o 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0837.xml |
| 035 | |a (DE-627)NLM251115445 | ||
| 035 | |a (NLM)26198766 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Horwitz, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Desflurane and sevoflurane use during low- and minimal-flow anesthesia at fixed vaporizer settings |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 23.02.2017 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Minerva Anestesiol. 2016 Feb;82(2):149-50. - PMID 26449777 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The pharmacokinetics for sevoflurane and desflurane makes them suitable for low-flow anesthesia. The aim of the present study was to assess the use of desflurane and sevoflurane at constant vaporizer settings and fixed low fresh gas flows | ||
| 520 | |a METHODS: One hundred ASA 1-2 patients undergoing elective laparoscopic surgery were randomized into 4 groups (25 patients each): a fixed fresh gas flow 1.0 or 0.5 L/min with desflurane (D1.0 and D0.5) or sevoflurane (S1.0 and S0.5) throughout anesthesia. A fixed vaporizer setting, sevoflurane 6% and desflurane 18% was used during wash-in. Time to reach 1 and 1.5 minimum alveolar concentration (MAC), emergence and gas consumption from start to end of surgery was studied | ||
| 520 | |a RESULTS: Time to reach 1 MAC age adjusted desflurane or sevoflurane was D0.5 8.5±1.7, D1.0 3.7±0.7, S0.5 15.2±2.4 and S1.0 6.2±1.3 minutes, respectively (P<0.001), and times to increase from 1 to 1.5 MAC differed also significantly. Desflurane anesthesia was associated to significantly shorter time to extubation 6.7±2.3 vs. 10±2.3 minutes for sevoflurane (P<0.001). The amount of agent consumed g/min. was significantly reduced for both 0.5 L/min groups: 30% less for desflurane and 19% for sevoflurane | ||
| 520 | |a CONCLUSIONS: We found an almost twice as rapid wash-in with desflurane and expectedly faster emergence. Gas consumption was lower at 0.5 L/min than it was at 1 L/min for both gases studied however most pronounced for desflurane. Desflurane has clear advantages for minimal fresh gas flow anesthesia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Anesthetics, Inhalation |2 NLM | |
| 650 | 7 | |a Methyl Ethers |2 NLM | |
| 650 | 7 | |a Sevoflurane |2 NLM | |
| 650 | 7 | |a 38LVP0K73A |2 NLM | |
| 650 | 7 | |a Desflurane |2 NLM | |
| 650 | 7 | |a CRS35BZ94Q |2 NLM | |
| 650 | 7 | |a Isoflurane |2 NLM | |
| 650 | 7 | |a CYS9AKD70P |2 NLM | |
| 700 | 1 | |a Jakobsson, Jan G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Minerva anestesiologica |d 1953 |g 82(2016), 2 vom: 12. Feb., Seite 180-5 |w (DE-627)NLM000043397 |x 1827-1596 |7 nnns |
| 773 | 1 | 8 | |g volume:82 |g year:2016 |g number:2 |g day:12 |g month:02 |g pages:180-5 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 82 |j 2016 |e 2 |b 12 |c 02 |h 180-5 | ||