High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Infection ecology & epidemiology - 5(2015) vom: 17., Seite 28305 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Farag, Elmoubasher A B A [VerfasserIn] |
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| Anmerkungen: |
Date Completed 18.07.2015 Date Revised 30.09.2020 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3402/iee.v5.28305 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM250963302 |
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| 520 | |a Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Haagmans, Bart L |e verfasserin |4 aut | |
| 700 | 1 | |a Mohran, Khaled A |e verfasserin |4 aut | |
| 700 | 1 | |a Stalin Raj, V |e verfasserin |4 aut | |
| 700 | 1 | |a Pas, Suzan D |e verfasserin |4 aut | |
| 700 | 1 | |a Voermans, Jolanda |e verfasserin |4 aut | |
| 700 | 1 | |a Smits, Saskia L |e verfasserin |4 aut | |
| 700 | 1 | |a Godeke, Gert-Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Hajri, Mohd M |e verfasserin |4 aut | |
| 700 | 1 | |a Alhajri, Farhoud H |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Romaihi, Hamad E |e verfasserin |4 aut | |
| 700 | 1 | |a Ghobashy, Hazem |e verfasserin |4 aut | |
| 700 | 1 | |a El-Maghraby, Mamdouh M |e verfasserin |4 aut | |
| 700 | 1 | |a El-Sayed, Ahmed M |e verfasserin |4 aut | |
| 700 | 1 | |a Al Thani, Mohamed H J |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Marri, Salih |e verfasserin |4 aut | |
| 700 | 1 | |a Koopmans, Marion P G |e verfasserin |4 aut | |
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