Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits
Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Pharmaceutical development and technology - 21(2016), 7 vom: 30. Nov., Seite 787-793 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wu, Xingxing [VerfasserIn] |
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| Themen: |
63LT81K70N |
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| Anmerkungen: |
Date Completed 15.03.2017 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM250423278 |
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| 245 | 1 | 0 | |a Sinomenine hydrochloride-loaded dissolving microneedles enhanced its absorption in rabbits |
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| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Sinomenine hydrochloride-loaded dissolving microneedles (SH-DM) were fabricated by maltose and poly-lactic-co-glycolic acid using a casting method. The mechanical strength of SH-DM was investigated by an insertion test. In vivo transdermal absorption experiment was performed to evaluate the percutaneous absorption of SH-DM, sinomenine hydrochloride gel (SH-G) was used as a control. The results demonstrated that prepared SH-DM was morphologically intact with sufficient mechanical strength after inserting into aluminum foil and rat skin. The value of area under curve obtained after administration of SH-DM through transdermal in rabbits showed a significantly rise and was 1.99 times higher than that of SH-G, and the relative bioavailability value was 199.21%. These results showed that SH-DM enhanced bioavailability and permeability of SH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dissolving microneedle | |
| 650 | 4 | |a sinomenine hydrochloride | |
| 650 | 4 | |a transdermal drug delivery | |
| 650 | 7 | |a Morphinans |2 NLM | |
| 650 | 7 | |a sinomenine |2 NLM | |
| 650 | 7 | |a 63LT81K70N |2 NLM | |
| 700 | 1 | |a Chen, Yulin |e verfasserin |4 aut | |
| 700 | 1 | |a Gui, Shuangying |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Xiaoqing |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Yingji |e verfasserin |4 aut | |
| 700 | 1 | |a Yin, Dengke |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Ping |e verfasserin |4 aut | |
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