Autologous hematopoietic stem cell transplantation in elderly patients (≥ 70 years) with non-Hodgkin's lymphoma : A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study
Copyright © 2015 Elsevier Inc. All rights reserved..
INTRODUCTION: Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL).
MATERIALS AND METHODS: In the setting of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) group, we retrospectively analyzed 81 consecutive patients with NHL over 70 years of age who received AHSCT.
RESULTS: The median age at AHSCT was 72.3 years [70-80]. Patients' were diagnosed with diffuse large B-cell lymphoma (n=40), follicular lymphoma (n=16), mantle cell lymphoma (n=15), T-cell lymphoma (n=5), and other (n=5). Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) was 0 in 73% of patients. Main conditionings were BEAM (Carmustine-Etoposide-Cytarabine-Melphalan, n=61) and melphalan alone (n=14). Median delays to reach 0.5×10⁹/L neutrophils and 20 × 10(9)/L platelets were of 12 [9-76] days and 12 [0-143] days, respectively. One hundred day and one year cumulative incidence of NRM was 5.4% and 8.5%, respectively. The main cause of death remains relapse.
CONCLUSION: In conclusion, this study revealed that AHSCT seemed to be acceptable in patients over 70 years of age with NHL. Patient age is not a limiting factor if clinical condition is adequate.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:6 |
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| Enthalten in: |
Journal of geriatric oncology - 6(2015), 5 vom: 22. Sept., Seite 346-52 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hermet, E [VerfasserIn] |
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| Links: |
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| Themen: |
Autologous stem cell transplantation |
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| Anmerkungen: |
Date Completed 14.07.2016 Date Revised 03.10.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jgo.2015.04.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM250356732 |
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| 245 | 1 | 0 | |a Autologous hematopoietic stem cell transplantation in elderly patients (≥ 70 years) with non-Hodgkin's lymphoma |b A French Society of Bone Marrow Transplantation and Cellular Therapy retrospective study |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 14.07.2016 | ||
| 500 | |a Date Revised 03.10.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: Limited data is available on the feasibility of high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (AHSCT) in elderly patients over 70 years of age with non-Hodgkin's lymphoma (NHL) | ||
| 520 | |a MATERIALS AND METHODS: In the setting of the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) group, we retrospectively analyzed 81 consecutive patients with NHL over 70 years of age who received AHSCT | ||
| 520 | |a RESULTS: The median age at AHSCT was 72.3 years [70-80]. Patients' were diagnosed with diffuse large B-cell lymphoma (n=40), follicular lymphoma (n=16), mantle cell lymphoma (n=15), T-cell lymphoma (n=5), and other (n=5). Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) was 0 in 73% of patients. Main conditionings were BEAM (Carmustine-Etoposide-Cytarabine-Melphalan, n=61) and melphalan alone (n=14). Median delays to reach 0.5×10⁹/L neutrophils and 20 × 10(9)/L platelets were of 12 [9-76] days and 12 [0-143] days, respectively. One hundred day and one year cumulative incidence of NRM was 5.4% and 8.5%, respectively. The main cause of death remains relapse | ||
| 520 | |a CONCLUSION: In conclusion, this study revealed that AHSCT seemed to be acceptable in patients over 70 years of age with NHL. Patient age is not a limiting factor if clinical condition is adequate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Autologous stem cell transplantation | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a High dose chemotherapy | |
| 650 | 4 | |a Non-Hodgkin lymphoma | |
| 650 | 4 | |a Treatment related mortality | |
| 700 | 1 | |a Cabrespine, A |e verfasserin |4 aut | |
| 700 | 1 | |a Guièze, R |e verfasserin |4 aut | |
| 700 | 1 | |a Garnier, A |e verfasserin |4 aut | |
| 700 | 1 | |a Tempescul, A |e verfasserin |4 aut | |
| 700 | 1 | |a Lenain, P |e verfasserin |4 aut | |
| 700 | 1 | |a Bouabdallah, R |e verfasserin |4 aut | |
| 700 | 1 | |a Vilque, J P |e verfasserin |4 aut | |
| 700 | 1 | |a Frayfer, J |e verfasserin |4 aut | |
| 700 | 1 | |a Bordessoule, D |e verfasserin |4 aut | |
| 700 | 1 | |a Sibon, D |e verfasserin |4 aut | |
| 700 | 1 | |a Janvier, M |e verfasserin |4 aut | |
| 700 | 1 | |a Caillot, D |e verfasserin |4 aut | |
| 700 | 1 | |a Biron, P |e verfasserin |4 aut | |
| 700 | 1 | |a Legros, L |e verfasserin |4 aut | |
| 700 | 1 | |a Choufi, B |e verfasserin |4 aut | |
| 700 | 1 | |a Drenou, B |e verfasserin |4 aut | |
| 700 | 1 | |a Gorin, N C |e verfasserin |4 aut | |
| 700 | 1 | |a Bilger, K |e verfasserin |4 aut | |
| 700 | 1 | |a Tamburini, J |e verfasserin |4 aut | |
| 700 | 1 | |a Soussain, C |e verfasserin |4 aut | |
| 700 | 1 | |a Brechignac, S |e verfasserin |4 aut | |
| 700 | 1 | |a Bay, J O |e verfasserin |4 aut | |
| 700 | 0 | |a Société Française de Greffe de Moelle et de Thérapie Cellulaire |e verfasserin |4 aut | |
| 700 | 1 | |a Hermet, E |e investigator |4 oth | |
| 700 | 1 | |a Bay, J O |e investigator |4 oth | |
| 700 | 1 | |a Garnier, A |e investigator |4 oth | |
| 700 | 1 | |a Tempescul, A |e investigator |4 oth | |
| 700 | 1 | |a Lenain, P |e investigator |4 oth | |
| 700 | 1 | |a Bouabdallah, R |e investigator |4 oth | |
| 700 | 1 | |a Vilque, J P |e investigator |4 oth | |
| 700 | 1 | |a Frayfer, J |e investigator |4 oth | |
| 700 | 1 | |a Bordessoule, D |e investigator |4 oth | |
| 700 | 1 | |a Sibon, D |e investigator |4 oth | |
| 700 | 1 | |a Janvier, M |e investigator |4 oth | |
| 700 | 1 | |a Caillot, D |e investigator |4 oth | |
| 700 | 1 | |a Biron, P |e investigator |4 oth | |
| 700 | 1 | |a Legros, L |e investigator |4 oth | |
| 700 | 1 | |a Choufi, B |e investigator |4 oth | |
| 700 | 1 | |a Drenou, B |e investigator |4 oth | |
| 700 | 1 | |a Gorin, N C |e investigator |4 oth | |
| 700 | 1 | |a Bilger, K |e investigator |4 oth | |
| 700 | 1 | |a Tamburini, J |e investigator |4 oth | |
| 700 | 1 | |a Soussain, C |e investigator |4 oth | |
| 700 | 1 | |a Brechignac, S |e investigator |4 oth | |
| 700 | 1 | |a Cabrespine, A |e investigator |4 oth | |
| 700 | 1 | |a Guieze, R |e investigator |4 oth | |
| 700 | 1 | |a Bay, J O |e investigator |4 oth | |
| 700 | 1 | |a Hermet, B |e investigator |4 oth | |
| 700 | 1 | |a Cabrespine, A |e investigator |4 oth | |
| 700 | 1 | |a Cabrespine, A |e investigator |4 oth | |
| 700 | 1 | |a Guieze, R |e investigator |4 oth | |
| 700 | 1 | |a Bay, J O |e investigator |4 oth | |
| 700 | 1 | |a Hermet, E |e investigator |4 oth | |
| 700 | 1 | |a Cabrespine, A |e investigator |4 oth | |
| 700 | 1 | |a Guieze, R |e investigator |4 oth | |
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