Success of endoscopic ultrasound-guided ethanol ablation of pancreatic cysts : a meta-analysis and systematic review
BACKGROUND: Endoscopic ultrasound (EUS)-guided ethanol ablation has emerged as an efficacious and safe alternative management option for pancreatic cysts. We undertook a meta-analysis and systematic review to assess the overall safety and efficacy of EUS-guided ethanol ablation of pancreatic cysts.
METHOD STUDY SELECTION CRITERIA: EUS-guided ethanol ablation of pancreatic cysts.
DATA COLLECTION EXTRACTION: Articles were searched in Medline, Pubmed, and Ovid journals.
STATISTICAL METHOD: Fixed and random effects models were used to calculate the pooled proportions.
RESULTS: Initial search identified 1,319 reference articles, in which 120 relevant articles were selected and reviewed. Data was extracted from seven studies (n = 152) of EUS-guided ethanol ablation of pancreatic cysts, which met the inclusion criteria. With EUS-guided ethanol ablation, the pooled proportion of patients with complete cyst resolution was 56.20 % (95 % CI = 48.16 to 64.08) and partial cyst resolution was 23.72 % (95 % CI = 17.24 to 30.89). Postprocedural complications after ablation were significant for abdominal pain in 6.51 % (95 % CI = 3.12 to 11.04) and pancreatitis in 3.90 % (95 % CI = 1.39 to 7.60) of the pooled percentage of patients. Publication bias calculated using Harbord-Egger bias indicator gave a value of -1.09 (95 % CI = 10.21 to 8.03, p = 0.77). The Begg-Mazumdar indicator gave a Kendall's tau b value of 0.05 (p ≥ 0.99).
CONCLUSIONS: EUS-guided ethanol ablation may be a safe alternative treatment modality for pancreatic cysts, with acceptable intraprocedural and postprocedural complications. However, due to the limited data available, prospective randomized controlled trials with a long follow up period are required in this area.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
|---|---|
| Enthalten in: |
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology - 34(2015), 3 vom: 25. Mai, Seite 193-9 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Kandula, Manasa [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
3K9958V90M |
|---|
| Anmerkungen: |
Date Completed 13.12.2016 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s12664-015-0575-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM25028474X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM25028474X | ||
| 003 | DE-627 | ||
| 005 | 20231224155413.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12664-015-0575-2 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0834.xml |
| 035 | |a (DE-627)NLM25028474X | ||
| 035 | |a (NLM)26108653 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Kandula, Manasa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Success of endoscopic ultrasound-guided ethanol ablation of pancreatic cysts |b a meta-analysis and systematic review |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.12.2016 | ||
| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Endoscopic ultrasound (EUS)-guided ethanol ablation has emerged as an efficacious and safe alternative management option for pancreatic cysts. We undertook a meta-analysis and systematic review to assess the overall safety and efficacy of EUS-guided ethanol ablation of pancreatic cysts | ||
| 520 | |a METHOD STUDY SELECTION CRITERIA: EUS-guided ethanol ablation of pancreatic cysts | ||
| 520 | |a DATA COLLECTION EXTRACTION: Articles were searched in Medline, Pubmed, and Ovid journals | ||
| 520 | |a STATISTICAL METHOD: Fixed and random effects models were used to calculate the pooled proportions | ||
| 520 | |a RESULTS: Initial search identified 1,319 reference articles, in which 120 relevant articles were selected and reviewed. Data was extracted from seven studies (n = 152) of EUS-guided ethanol ablation of pancreatic cysts, which met the inclusion criteria. With EUS-guided ethanol ablation, the pooled proportion of patients with complete cyst resolution was 56.20 % (95 % CI = 48.16 to 64.08) and partial cyst resolution was 23.72 % (95 % CI = 17.24 to 30.89). Postprocedural complications after ablation were significant for abdominal pain in 6.51 % (95 % CI = 3.12 to 11.04) and pancreatitis in 3.90 % (95 % CI = 1.39 to 7.60) of the pooled percentage of patients. Publication bias calculated using Harbord-Egger bias indicator gave a value of -1.09 (95 % CI = 10.21 to 8.03, p = 0.77). The Begg-Mazumdar indicator gave a Kendall's tau b value of 0.05 (p ≥ 0.99) | ||
| 520 | |a CONCLUSIONS: EUS-guided ethanol ablation may be a safe alternative treatment modality for pancreatic cysts, with acceptable intraprocedural and postprocedural complications. However, due to the limited data available, prospective randomized controlled trials with a long follow up period are required in this area | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Systematic Review | |
| 650 | 7 | |a Ethanol |2 NLM | |
| 650 | 7 | |a 3K9958V90M |2 NLM | |
| 700 | 1 | |a Moole, Harsha |e verfasserin |4 aut | |
| 700 | 1 | |a Cashman, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Volmar, Fritz H |e verfasserin |4 aut | |
| 700 | 1 | |a Bechtold, Matthew L |e verfasserin |4 aut | |
| 700 | 1 | |a Puli, Srinivas R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology |d 1993 |g 34(2015), 3 vom: 25. Mai, Seite 193-9 |w (DE-627)NLM012713031 |x 0975-0711 |7 nnns |
| 773 | 1 | 8 | |g volume:34 |g year:2015 |g number:3 |g day:25 |g month:05 |g pages:193-9 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s12664-015-0575-2 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 34 |j 2015 |e 3 |b 25 |c 05 |h 193-9 | ||