Stability studies of cefoselis sulfate in the solid state
Copyright © 2015 Elsevier B.V. All rights reserved..
The process of degradation was studied by using an HPLC-DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefoselis sulfate was investigated. In the solid state at increased RH the degradation of cefoselis sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
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| Enthalten in: |
Journal of pharmaceutical and biomedical analysis - 114(2015) vom: 10. Okt., Seite 222-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zalewski, Przemysław [VerfasserIn] |
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| Links: |
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| Themen: |
0B50MLU3H1 |
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| Anmerkungen: |
Date Completed 08.06.2016 Date Revised 13.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jpba.2015.05.033 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM249945231 |
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| 520 | |a Copyright © 2015 Elsevier B.V. All rights reserved. | ||
| 520 | |a The process of degradation was studied by using an HPLC-DAD method. Two degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefoselis sulfate was investigated. In the solid state at increased RH the degradation of cefoselis sulfate was an autocatalytic reaction of the first order with respect to substrate concentration while in dry air was first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cefoselis sulfate | |
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| 650 | 4 | |a Q-TOF | |
| 650 | 4 | |a Stability in solid state | |
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| 700 | 1 | |a Talaczyńska, Alicja |e verfasserin |4 aut | |
| 700 | 1 | |a Paczkowska, Magdalena |e verfasserin |4 aut | |
| 700 | 1 | |a Garbacki, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Cielecka-Piontek, Judyta |e verfasserin |4 aut | |
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