Fatal intracerebral haemorrhage possibly caused by interaction between paracetamol and warfarin
This is a case report of an 83-year-old man in warfarin treatment with stable international normalised ratio (INR) after aortic valve replacement and atrial fibrillation. Due to back pain he took paracetamol (acetaminophen) 4 g/day, morphine 30 mg/day and diclofenac as rescue medication for two weeks. After 14 days of treatment he was admitted to a hospital with acute neurological deficits, and a blood sample showed INR levels above 10. A CT-scan of the brain showed an intracerebral haemorrhage. The patient died eight days after admission. Mechanisms of the possible interaction between paracetamol and warfarin are discussed.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:177 |
|---|---|
| Enthalten in: |
Ugeskrift for laeger - 177(2015), 23 vom: 01. Juni, Seite V12140685 |
| Sprache: |
Dänisch |
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| Weiterer Titel: |
Fatal cerebral blødning på grund af mulig interaktionmellem paracetamol og warfarin |
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| Beteiligte Personen: |
Naver, Signe Vinsand [VerfasserIn] |
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| Themen: |
362O9ITL9D |
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| Anmerkungen: |
Date Completed 09.11.2017 Date Revised 09.11.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249803577 |
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| 520 | |a This is a case report of an 83-year-old man in warfarin treatment with stable international normalised ratio (INR) after aortic valve replacement and atrial fibrillation. Due to back pain he took paracetamol (acetaminophen) 4 g/day, morphine 30 mg/day and diclofenac as rescue medication for two weeks. After 14 days of treatment he was admitted to a hospital with acute neurological deficits, and a blood sample showed INR levels above 10. A CT-scan of the brain showed an intracerebral haemorrhage. The patient died eight days after admission. Mechanisms of the possible interaction between paracetamol and warfarin are discussed | ||
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