Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort
Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissionsoup.com..
BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis.
METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu].
RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93].
CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres.
| Errataetall: |
ErratumIn: J Crohns Colitis. 2015 Oct;9(10):939. - PMID 26417056 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Journal of Crohn's & colitis - 9(2015), 9 vom: 07. Sept., Seite 747-53 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vegh, Z [VerfasserIn] |
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| Links: |
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| Themen: |
Comparative Study |
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| Anmerkungen: |
Date Completed 31.05.2016 Date Revised 09.04.2022 published: Print-Electronic ErratumIn: J Crohns Colitis. 2015 Oct;9(10):939. - PMID 26417056 Citation Status MEDLINE |
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| doi: |
10.1093/ecco-jcc/jjv099 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249779684 |
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| 245 | 1 | 0 | |a Treatment Steps, Surgery, and Hospitalization Rates During the First Year of Follow-up in Patients with Inflammatory Bowel Diseases from the 2011 ECCO-Epicom Inception Cohort |
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| 500 | |a Date Revised 09.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: J Crohns Colitis. 2015 Oct;9(10):939. - PMID 26417056 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
| 520 | |a BACKGROUND AND AIMS: The ECCO-EpiCom study investigates the differences in the incidence and therapeutic management of inflammatory bowel diseases [IBD] between Eastern and Western Europe. The aim of this study was to analyse the differences in the disease phenotype, medical therapy, surgery, and hospitalization rates in the ECCO-EpiCom 2011 inception cohort during the first year after diagnosis | ||
| 520 | |a METHODS: Nine Western, five Eastern European centres and one Australian centre with 258 Crohn's disease [CD], 380 ulcerative colitis [UC] and 71 IBD unclassified [IBDU] patients [female/male: 326/383; mean age at diagnosis: 40.9 years, SD: 17.3 years] participated. Patients' data were registered and entered in the web-based ECCO-EpiCom database [www.epicom-ecco.eu] | ||
| 520 | |a RESULTS: In CD, 36 [19%] Western Europe/Australian and 6 [9%] Eastern European patients received biological therapy [p = 0.04], but the immunosuppressive [IS] use was equal and high in these regions [Eastern Europe vs Western Europe/Australia: 53% vs 45%; p = 0.27]. Surgery was performed in 17 [24%] CD patients in Eastern Europe and 13 [7%] in Western Europe/Australia [p < 0.001, pLogRank = 0.001]. Of CD patients from Eastern Europe, 24 [34%] were hospitalized, and 39 [21%] from Western Europe/Australia, [p = 0.02, pLogRank = 0.01]. In UC, exposure to biologicals and colectomy rates were low and hospitalization rates did not differ between these regions during the 1-year follow-up period [16% vs 16%; p = 0.93] | ||
| 520 | |a CONCLUSIONS: During the first year after diagnosis, surgery and hospitalization rates were significantly higher in CD patients in Eastern Europe compared with Western Europe/Australia, whereas significantly more CD patients were treated with biologicals in the Western Europe/Australian centres | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Inflammatory bowel diseases | |
| 650 | 4 | |a hospitalization | |
| 650 | 4 | |a surgery | |
| 650 | 7 | |a Immunosuppressive Agents |2 NLM | |
| 700 | 1 | |a Burisch, J |e verfasserin |4 aut | |
| 700 | 1 | |a Pedersen, N |e verfasserin |4 aut | |
| 700 | 1 | |a Kaimakliotis, I |e verfasserin |4 aut | |
| 700 | 1 | |a Duricova, D |e verfasserin |4 aut | |
| 700 | 1 | |a Bortlik, M |e verfasserin |4 aut | |
| 700 | 1 | |a Vinding, K Kofod |e verfasserin |4 aut | |
| 700 | 1 | |a Avnstrøm, S |e verfasserin |4 aut | |
| 700 | 1 | |a Olsen, J |e verfasserin |4 aut | |
| 700 | 1 | |a Nielsen, K R |e verfasserin |4 aut | |
| 700 | 1 | |a Katsanos, K H |e verfasserin |4 aut | |
| 700 | 1 | |a Tsianos, E V |e verfasserin |4 aut | |
| 700 | 1 | |a Lakatos, L |e verfasserin |4 aut | |
| 700 | 1 | |a Schwartz, D |e verfasserin |4 aut | |
| 700 | 1 | |a Odes, S |e verfasserin |4 aut | |
| 700 | 1 | |a D'Incà, R |e verfasserin |4 aut | |
| 700 | 1 | |a Beltrami, M |e verfasserin |4 aut | |
| 700 | 1 | |a Kiudelis, G |e verfasserin |4 aut | |
| 700 | 1 | |a Kupcinskap, L |e verfasserin |4 aut | |
| 700 | 1 | |a Jucov, A |e verfasserin |4 aut | |
| 700 | 1 | |a Turcan, S |e verfasserin |4 aut | |
| 700 | 1 | |a Barros, L F |e verfasserin |4 aut | |
| 700 | 1 | |a Magro, F |e verfasserin |4 aut | |
| 700 | 1 | |a Lazar, D |e verfasserin |4 aut | |
| 700 | 1 | |a Goldis, A |e verfasserin |4 aut | |
| 700 | 1 | |a de Castro, L |e verfasserin |4 aut | |
| 700 | 1 | |a Hernandez, V |e verfasserin |4 aut | |
| 700 | 1 | |a Niewiadomski, O |e verfasserin |4 aut | |
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| 700 | 1 | |a Kaimaklitois, I |e investigator |4 oth | |
| 700 | 1 | |a Duricova, D |e investigator |4 oth | |
| 700 | 1 | |a Bortlik, M |e investigator |4 oth | |
| 700 | 1 | |a Avnstrøm, S |e investigator |4 oth | |
| 700 | 1 | |a Kofod Vinding, K |e investigator |4 oth | |
| 700 | 1 | |a Olsen, J |e investigator |4 oth | |
| 700 | 1 | |a Nielsen, K R |e investigator |4 oth | |
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| 700 | 1 | |a Lakatos, L |e investigator |4 oth | |
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| 700 | 1 | |a Odes, S |e investigator |4 oth | |
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| 700 | 1 | |a Kupcinskap, L |e investigator |4 oth | |
| 700 | 1 | |a Jucov, A |e investigator |4 oth | |
| 700 | 1 | |a Turcan, S |e investigator |4 oth | |
| 700 | 1 | |a Barros, L F |e investigator |4 oth | |
| 700 | 1 | |a Magro, F |e investigator |4 oth | |
| 700 | 1 | |a Lazar, D |e investigator |4 oth | |
| 700 | 1 | |a Goldis, A |e investigator |4 oth | |
| 700 | 1 | |a de Castro, L |e investigator |4 oth | |
| 700 | 1 | |a Hernandez, V |e investigator |4 oth | |
| 700 | 1 | |a Niewiadomski, O |e investigator |4 oth | |
| 700 | 1 | |a Bell, S |e investigator |4 oth | |
| 700 | 1 | |a Langholz, E |e investigator |4 oth | |
| 700 | 1 | |a Munkholm, P |e investigator |4 oth | |
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| 700 | 1 | |a Williams, J |e investigator |4 oth | |
| 700 | 1 | |a Nicolaou, A |e investigator |4 oth | |
| 700 | 1 | |a Weimers, P |e investigator |4 oth | |
| 700 | 1 | |a Seerup, R |e investigator |4 oth | |
| 700 | 1 | |a Stroggili, K |e investigator |4 oth | |
| 700 | 1 | |a Demenyi, G |e investigator |4 oth | |
| 700 | 1 | |a Kramli, S |e investigator |4 oth | |
| 700 | 1 | |a Giannotta, M |e investigator |4 oth | |
| 700 | 1 | |a De Padova, A |e investigator |4 oth | |
| 700 | 1 | |a Jonaitis, L |e investigator |4 oth | |
| 700 | 1 | |a Valantiene, I |e investigator |4 oth | |
| 700 | 1 | |a Fernandez, A |e investigator |4 oth | |
| 700 | 1 | |a Sanroman, L |e investigator |4 oth | |
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