Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population : receiver operating characteristic curve analysis
Copyright © 2015 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved..
OBJECTIVE: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns.
METHODS: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0g/dL and newborns with cord Hb <13.0g/dL were classified as anemic. A serum ferritin <12.0μg/L in women and a cord blood serum ferritin <35.0μg/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores.
RESULTS: The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0μg/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200).
CONCLUSION: Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Revista brasileira de hematologia e hemoterapia - 37(2015), 3 vom: 04. Mai, Seite 178-83 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jaime-Pérez, José Carlos [VerfasserIn] |
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| Links: |
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| Themen: |
Anemia, Iron-deficiency |
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| Anmerkungen: |
Date Completed 04.06.2015 Date Revised 31.03.2022 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.bjhh.2015.02.002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Evaluation of hemoglobin performance in the assessment of iron stores in feto-maternal pairs in a high-risk population |b receiver operating characteristic curve analysis |
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| 500 | |a Date Completed 04.06.2015 | ||
| 500 | |a Date Revised 31.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2015 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved. | ||
| 520 | |a OBJECTIVE: By applying receiver operating characteristic curve analysis, the objective of this study was to see whether hemoglobin levels reflect body iron stores in a group of pregnant women at term who, by using serum ferritin as the reference test, had a high pre-test probability of having iron deficiency anemia. Likewise, we evaluated the ability of hemoglobin and maternal serum ferritin levels to predict iron deficiency anemia in newborns | ||
| 520 | |a METHODS: Hemoglobin and serum ferritin were measured in 187 pregnant women at term belonging to a group with a high pre-test probability of iron deficiency anemia and their newborns. Women with Hb <11.0g/dL and newborns with cord Hb <13.0g/dL were classified as anemic. A serum ferritin <12.0μg/L in women and a cord blood serum ferritin <35.0μg/L were considered to reflect empty iron stores. Receiver operating characteristic curve analysis was applied to select the cut-off points that better reflected iron stores | ||
| 520 | |a RESULTS: The Hb cut-off point selected by receiver operating characteristic curve analysis in women was <11.5g/dL (sensitivity: 60.82, specificity: 53.33%, Youden Index: 0.450). Most of the newborns had normal Hb which precluded this analysis. Maternal Hb <11.0g/dL was the cut-off point that best reflected iron deficiency anemia in newborns (sensitivity: 55.88%, specificity: 57.24%, Youden Index: 0.217). The best cut-off point of maternal serum ferritin to reflect empty iron stores in newborns was <6.0μg/L (sensitivity: 76.47%, specificity: 31.58%, Youden Index: 0.200) | ||
| 520 | |a CONCLUSION: Hemoglobin concentration performed poorly to detect iron deficiency anemia in women at term with high risk for iron deficiency and their newborns | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anemia, Iron-deficiency | |
| 650 | 4 | |a Diagnostic tests, Routine | |
| 650 | 4 | |a Ferritins | |
| 700 | 1 | |a García-Arellano, Gisela |e verfasserin |4 aut | |
| 700 | 1 | |a Méndez-Ramírez, Nereida |e verfasserin |4 aut | |
| 700 | 1 | |a González-Llano, Óscar |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Almaguer, David |e verfasserin |4 aut | |
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