Detection of serum antibodies against Japanese encephalitis virus in bats in Hainan and Guangdong Provinces of China
OBJECTIVE: To investigate the prevalence of serum antibodies against Japanese encephalitis virus (JEV) in bats.
METHODS: Blood samples from the heart were obtained from bats captured in Guangdong and Hainan Provinces in 2013. The anti-JEV antibodies in bat sera were tested using indirect ELISA and virus neutralization test.
RESULTS: A total of 201 bat serum samples were tested, in which the total positivity rate of anti-JEV antibodies was 46.27% (93/201). The positive rate of anti-JEV antibodies in bats from Hainan and Guangdong Provinces was 88.89% (48/54) and 30.61% (45/147), respectively. All the samples from Rousettus leschenaultia, Miniopterus schreibersii, Pipistrellus abramus, and Rhinolophus macrotis were positive for anti-JEV antibodies, and up to 95.56% (43/45) of the samples from Miniopterus schreibersii (from Hainan Province) yielded positive results. Of the 28 samples with positive results by indirect ELISA, 15 showed positive results in virus neutralization test (53.57%) with neutralization antibody titers ranging from 1:10 to 1:28.22.
CONCLUSION: Bats from different regions and of different species can be naturally infected with JEV and have a high prevalence of anti-JEV antibodies in their sera. The role of bats in the natural cycle of JEV awaits further study.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2015 |
|---|---|
| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
|---|---|
| Enthalten in: |
Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 35(2015), 5 vom: 28. Mai, Seite 720-3 |
| Sprache: |
Chinesisch |
|---|
| Beteiligte Personen: |
Jiang, Lina [VerfasserIn] |
|---|
| Themen: |
Antibodies, Viral |
|---|
| Anmerkungen: |
Date Completed 20.07.2015 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249413760 |
|---|
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| 245 | 1 | 0 | |a Detection of serum antibodies against Japanese encephalitis virus in bats in Hainan and Guangdong Provinces of China |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 20.07.2015 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To investigate the prevalence of serum antibodies against Japanese encephalitis virus (JEV) in bats | ||
| 520 | |a METHODS: Blood samples from the heart were obtained from bats captured in Guangdong and Hainan Provinces in 2013. The anti-JEV antibodies in bat sera were tested using indirect ELISA and virus neutralization test | ||
| 520 | |a RESULTS: A total of 201 bat serum samples were tested, in which the total positivity rate of anti-JEV antibodies was 46.27% (93/201). The positive rate of anti-JEV antibodies in bats from Hainan and Guangdong Provinces was 88.89% (48/54) and 30.61% (45/147), respectively. All the samples from Rousettus leschenaultia, Miniopterus schreibersii, Pipistrellus abramus, and Rhinolophus macrotis were positive for anti-JEV antibodies, and up to 95.56% (43/45) of the samples from Miniopterus schreibersii (from Hainan Province) yielded positive results. Of the 28 samples with positive results by indirect ELISA, 15 showed positive results in virus neutralization test (53.57%) with neutralization antibody titers ranging from 1:10 to 1:28.22 | ||
| 520 | |a CONCLUSION: Bats from different regions and of different species can be naturally infected with JEV and have a high prevalence of anti-JEV antibodies in their sera. The role of bats in the natural cycle of JEV awaits further study | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Antibodies, Viral |2 NLM | |
| 700 | 1 | |a Chen, Shaowei |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Xueyan |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Shujuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Junhua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Qionghua |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xing |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Yiquan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Xueshan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhiyun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qing |e verfasserin |4 aut | |
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