Prognostic factors for the recurrence of sporadic desmoid-type fibromatosis after macroscopically complete resection : Analysis of 114 patients at a single institution
Copyright © 2015 Elsevier Ltd. All rights reserved..
AIMS: Desmoid-type fibromatoses (DFs) are rare soft-tissue neoplasms with frequent local recurrence. We sought to determine the prognostic factors that are predictive of recurrence-free survival (RFS) for these tumors.
METHODS: One hundred and fourteen consecutive patients with sporadic DF who received macroscopically complete resection (R0/R1) at a single tertiary hospital between 1985 and 2014 were included. A total of 10 clinical and pathological parameters were analyzed. Histologic slides and the margin status were re-checked; close margins (≤1-mm clearance) were noted separately and were considered together with the R1 margin.
RESULTS: The median follow-up interval was 72.5 months. Thirty-five (30.7%) patients had a local recurrence. The 2-, 5- and 10-year RFSs were 75.2%, 72.1% and 67.0%, respectively. In univariate analysis, age, tumor size, tumor site, margin status and presence of lesions at multiple sites had a significant impact on RFS. In multiple analysis, younger age (age<30 vs. age≥50 years: hazard ratio [HR] = 4.96; 95% confidence interval [95% CI], 1.50-16.4; p = 0.009); an extra-abdominal site (extra-abdominal site vs. other sites: HR = 4.08; 95% CI, 1.49-11.2; p = 0.006); larger tumor size (≥8 cm vs. <8 cm: HR = 2.43; 95% CI, 1.15-5.13; p = 0.021); and close or positive margin status (close margin/R1 vs. R0: HR = 2.64; 95% CI, 1.11-6.25; p = 0.027) were independent, unfavorable prognostic factors.
CONCLUSIONS: Different prognostic subgroups were identified that allow for the better selection of favorable therapeutic strategies. The role of the margin status should be considered with caution and should be based on a more precise pathological result.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 41(2015), 8 vom: 27. Aug., Seite 1013-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
He, X D [VerfasserIn] |
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| Links: |
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| Themen: |
Fibromatosis |
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| Anmerkungen: |
Date Completed 21.09.2015 Date Revised 25.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejso.2015.04.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM249311712 |
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| 100 | 1 | |a He, X D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prognostic factors for the recurrence of sporadic desmoid-type fibromatosis after macroscopically complete resection |b Analysis of 114 patients at a single institution |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 21.09.2015 | ||
| 500 | |a Date Revised 25.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 520 | |a AIMS: Desmoid-type fibromatoses (DFs) are rare soft-tissue neoplasms with frequent local recurrence. We sought to determine the prognostic factors that are predictive of recurrence-free survival (RFS) for these tumors | ||
| 520 | |a METHODS: One hundred and fourteen consecutive patients with sporadic DF who received macroscopically complete resection (R0/R1) at a single tertiary hospital between 1985 and 2014 were included. A total of 10 clinical and pathological parameters were analyzed. Histologic slides and the margin status were re-checked; close margins (≤1-mm clearance) were noted separately and were considered together with the R1 margin | ||
| 520 | |a RESULTS: The median follow-up interval was 72.5 months. Thirty-five (30.7%) patients had a local recurrence. The 2-, 5- and 10-year RFSs were 75.2%, 72.1% and 67.0%, respectively. In univariate analysis, age, tumor size, tumor site, margin status and presence of lesions at multiple sites had a significant impact on RFS. In multiple analysis, younger age (age<30 vs. age≥50 years: hazard ratio [HR] = 4.96; 95% confidence interval [95% CI], 1.50-16.4; p = 0.009); an extra-abdominal site (extra-abdominal site vs. other sites: HR = 4.08; 95% CI, 1.49-11.2; p = 0.006); larger tumor size (≥8 cm vs. <8 cm: HR = 2.43; 95% CI, 1.15-5.13; p = 0.021); and close or positive margin status (close margin/R1 vs. R0: HR = 2.64; 95% CI, 1.11-6.25; p = 0.027) were independent, unfavorable prognostic factors | ||
| 520 | |a CONCLUSIONS: Different prognostic subgroups were identified that allow for the better selection of favorable therapeutic strategies. The role of the margin status should be considered with caution and should be based on a more precise pathological result | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Fibromatosis | |
| 650 | 4 | |a Recurrence-free survival | |
| 650 | 4 | |a Risk factors | |
| 650 | 4 | |a Surgery | |
| 700 | 1 | |a Zhang, Y B |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, L |e verfasserin |4 aut | |
| 700 | 1 | |a Tian, M L |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, W |e verfasserin |4 aut | |
| 700 | 1 | |a Qu, Q |e verfasserin |4 aut | |
| 700 | 1 | |a Li, B L |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, T |e verfasserin |4 aut | |
| 700 | 1 | |a Li, N C |e verfasserin |4 aut | |
| 700 | 1 | |a Na, Y Q |e verfasserin |4 aut | |
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